{"id":"W2923068715","doi":"10.1002/mds.27643","title":"In vivo binding of a tau imaging probe, [<sup>11</sup>C]PBB3, in patients with progressive supranuclear palsy","year":2019,"lang":"en","type":"article","venue":"Movement Disorders","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"Innovation Cluster (Canada)","funders":"National Institute of Neurological Disorders and Stroke; Ministry of Education, Culture, Sports, Science and Technology; Mochida Memorial Foundation for Medical and Pharmaceutical Research; Japan Agency for Medical Research and Development","keywords":"Progressive supranuclear palsy; Benzothiazole; White matter; Pittsburgh compound B; Dentate nucleus; Medicine; Pathology; Cerebellum; Cerebellar cortex; Nuclear medicine; Neuroscience; Atrophy; Psychology; Alzheimer's disease; Magnetic resonance imaging; Chemistry; Internal medicine; Radiology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001849365,0.0004807917,0.000395365,0.0003472132,0.0004743969,0.0003092401,0.0002351392,0.000947151,0.0009368806],"category_scores_gemma":[0.0004806726,0.0004331405,0.0001738456,0.0002126435,0.0005276034,0.0001799516,0.0001607664,0.0005196864,0.0002610994],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006278043,"about_ca_system_score_gemma":0.0001750595,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008456883,"about_ca_topic_score_gemma":0.007200094,"domain_scores_codex":[0.9998567,0.00003167717,0.000008396714,0.00004956876,0.00001939309,0.00003422857],"domain_scores_gemma":[0.9998595,0.00004805656,0.00003498641,0.000006708113,0.00001651129,0.00003413852],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.007886639,0.0007568737,0.6566312,0.0001798295,0.0002781168,0.01792499,0.002318858,0.001570892,0.2931227,0.0001131378,0.0006159589,0.0186009],"study_design_scores_gemma":[0.000171914,0.002872589,0.9645517,0.00001127895,0.0001486888,0.01404244,0.0005099138,0.002005929,0.01498917,0.0001504055,0.000520539,0.00002526055],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994701,0.0001546952,0.0001032347,0.0000177789,0.000001464054,0.000003784419,0.00004417543,0.000008060626,0.0001968367],"genre_scores_gemma":[0.9996608,0.00005368672,0.00008354198,0.00002858711,9.680093e-7,0.000003396829,0.00003988434,0.00000178681,0.0001272262],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008456883,"threshold_uncertainty_score":0.0168153,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005687327695436063,"score_gpt":0.2506569563831125,"score_spread":0.2449696286876765,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}