{"id":"W2923069756","doi":"10.1002/anie.201902864","title":"Globular Polymer Grafts Require a Critical Size for Efficient Molecular Sieving of Enzyme Substrates","year":2019,"lang":"en","type":"article","venue":"Angewandte Chemie International Edition","topic":"Dendrimers and Hyperbranched Polymers","field":"Materials Science","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Dendrimer; Hydroxymethyl; Bovine serum albumin; Chemistry; Chymotrypsin; Polymer; Polymer chemistry; Combinatorial chemistry; Materials science; Enzyme; Stereochemistry; Organic chemistry; Chromatography; Trypsin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000155746,0.00035386,0.0001876447,0.0001108359,0.00007717399,0.000208893,0.0001642511,0.0002991816,0.0006735871],"category_scores_gemma":[0.0002249487,0.0001300131,0.0001385767,0.0001159605,0.0001718225,0.0003073361,0.0001563406,0.0003922874,0.0003242064],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002446602,"about_ca_system_score_gemma":0.0001356499,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001454483,"about_ca_topic_score_gemma":0.0003891549,"domain_scores_codex":[0.9999266,0.00001092272,0.000007424585,0.0000161549,0.0000194118,0.0000195796],"domain_scores_gemma":[0.9998291,0.00004018311,0.00006089809,0.00001761141,0.00002563528,0.00002663718],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001859362,0.000004239138,0.00004208437,0.00001726403,0.00000169613,0.00001469899,0.000005511631,0.00007123795,0.9993692,0.00006426268,0.000005782853,0.00038543],"study_design_scores_gemma":[0.000003293238,0.0001024933,0.0007920927,0.000002059745,0.00000365763,0.00006749798,0.000004764835,0.0002542723,0.9979364,0.00002713485,0.0008047758,0.000001615102],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9902667,0.0007846322,0.007600519,0.00005491861,0.00001722107,0.00003825106,0.00008263498,0.00005453631,0.001100588],"genre_scores_gemma":[0.9901819,0.0005906601,0.007098534,0.00003831408,0.000008255193,0.00004453026,0.0002057953,0.00002365124,0.001808395],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006735871,"threshold_uncertainty_score":0.002253413,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01033383841967272,"score_gpt":0.2696521578236686,"score_spread":0.2593183194039959,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}