{"id":"W2923110687","doi":"10.3390/cancers11040434","title":"The Contributions of Prostate Cancer Stem Cells in Prostate Cancer Initiation and Metastasis","year":2019,"lang":"en","type":"review","venue":"Cancers","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":110,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Joseph’s Healthcare Hamilton; McMaster University; St. Joseph's Hospital","funders":"Canadian Cancer Society; Cancer Research Society","keywords":"Prostate cancer; Cancer research; Cancer stem cell; Metastasis; PTEN; Stem cell; SOX2; Cancer; Biology; Cancer cell; Epithelial–mesenchymal transition; Cell biology; PI3K/AKT/mTOR pathway; Embryonic stem cell; Signal transduction; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003356478,0.0005305889,0.0008216747,0.001901304,0.0002895115,0.0007711161,0.000491717,0.0007381271,0.003686439],"category_scores_gemma":[0.0004282748,0.0001690985,0.000400192,0.001770303,0.0004284189,0.001007146,0.0005824579,0.001372068,0.001450727],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005938584,"about_ca_system_score_gemma":0.001082254,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001059139,"about_ca_topic_score_gemma":0.001916943,"domain_scores_codex":[0.9998878,0.00001832816,0.00001549143,0.00002033331,0.00004401203,0.00001407009],"domain_scores_gemma":[0.9997863,0.000108587,0.00002110904,0.000006373645,0.00005642347,0.00002123299],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005597389,0.00004980525,0.0002347563,0.01695873,0.00005667303,0.0002389676,0.00008144868,0.0003804494,0.00228215,0.007934942,0.0209516,0.9507745],"study_design_scores_gemma":[0.000008276738,0.00007763181,0.001059773,0.003198227,0.00006835751,0.001331519,0.00007147346,0.00006960131,0.0004529701,0.003134562,0.9905125,0.00001517566],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001187467,0.9981329,0.00009806087,0.0002544991,0.0001597737,0.000002409526,0.00001504835,0.00000574795,0.00121291],"genre_scores_gemma":[0.0005310564,0.9988287,0.00007453186,0.00010509,0.00008378891,0.000002677558,0.00001602351,6.898903e-7,0.000357507],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003686439,"threshold_uncertainty_score":0.01233232,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07674241583971482,"score_gpt":0.4053385941398259,"score_spread":0.3285961783001111,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}