{"id":"W2923271922","doi":"10.2217/bmt-2019-0005","title":"Germline Mutations and Their Clinical Applications in Cancer","year":2019,"lang":"en","type":"article","venue":"Breast Cancer Management","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Alberta Children's Hospital; National Research Council Canada","funders":"","keywords":"Medicine; Germline; Germline mutation; Breast cancer; Cancer; Internal medicine; Oncology; Mutation; Genetics; Gene; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008519146,0.0001011019,0.0001128013,0.00003834765,0.00002859439,0.00001844014,0.0001012448,0.00004878643,0.00007632552],"category_scores_gemma":[0.000001809565,0.00009171092,0.00004105775,0.00008631589,0.00003941425,0.000002539504,0.0001315855,0.00005071244,0.000007920257],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003176639,"about_ca_system_score_gemma":0.00004452671,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002692688,"about_ca_topic_score_gemma":0.000767167,"domain_scores_codex":[0.9992983,0.00001396575,0.0001869138,0.0003111835,0.00004443628,0.0001451982],"domain_scores_gemma":[0.9996096,0.00001361872,0.00005224355,0.0002395479,0.00003148328,0.00005346559],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001209367,0.0003152677,0.6972974,0.0001396093,0.0002470213,0.00000218023,0.0000845989,0.002578125,0.002419693,0.003781543,0.002762874,0.2902507],"study_design_scores_gemma":[0.001234767,0.00004427897,0.7778466,0.00003508932,0.00003481161,0.000003185737,0.0002269776,0.0003339018,0.0003251612,0.0003900756,0.2192925,0.0002326098],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907112,0.002966455,0.001007854,0.001247265,0.0002638412,0.0007751572,0.0003511611,0.00001006429,0.002667055],"genre_scores_gemma":[0.9909423,0.006616988,0.0001705922,0.0006606032,0.0002305408,0.0004596585,0.00008814885,0.00001605746,0.0008150992],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2900181,"threshold_uncertainty_score":0.3739863,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01032714851095669,"score_gpt":0.3009135572073341,"score_spread":0.2905864086963775,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}