{"id":"W2923306014","doi":"10.1101/589515","title":"Lipid Interactions of a Ciliary Membrane TRP Channel: Simulation and Structural Studies of Polycystin-2 (PC2)","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Genetic and Kidney Cyst Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Biotechnology and Biological Sciences Research Council; University of California, San Francisco; Innovative Medicines Initiative; Ontario Ministry of Economic Development and Innovation; Medical Research Council; Ministero dello Sviluppo Economico; Genome Canada; Fundação de Amparo à Pesquisa do Estado de São Paulo; National Institute of General Medical Sciences; Diamond Light Source; Wellcome Trust; Pfizer; Merck KGaA; Engineering and Physical Sciences Research Council; Eli Lilly and Company","keywords":"Transient receptor potential channel; Chemistry; Biophysics; Transmembrane domain; Subfamily; POPC; Phosphatidylinositol; Biochemistry; Cell biology; Membrane; Lipid bilayer; Biology; Signal transduction; Receptor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002072782,0.000449816,0.0006543052,0.0003045581,0.001006074,0.0005215936,0.0009321456,0.001042646,0.003008682],"category_scores_gemma":[0.000428415,0.0002905664,0.0005770414,0.0003355916,0.0006126022,0.0005709118,0.0004169199,0.0009069593,0.0002013813],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001224947,"about_ca_system_score_gemma":0.001205564,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01729403,"about_ca_topic_score_gemma":0.009045124,"domain_scores_codex":[0.9998848,0.00001604062,0.000004292319,0.00001606377,0.0000288972,0.00004995951],"domain_scores_gemma":[0.9997535,0.00009147519,0.00002387643,0.00002200166,0.00005197228,0.00005723454],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.000671909,0.0007692624,0.01014599,0.0001940618,0.0002063058,0.001229915,0.0003061791,0.9217871,0.05439555,0.004593736,0.001931186,0.003768705],"study_design_scores_gemma":[0.0001061089,0.0001023246,0.002333194,0.00000982268,0.00001831531,0.00004265053,0.00009099343,0.9931614,0.003258092,0.0005561588,0.0003069509,0.00001397534],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960533,0.0001171808,0.001145263,0.000254225,0.00002048665,0.00001522607,0.0002014231,0.00006845355,0.002124222],"genre_scores_gemma":[0.9981751,0.00007882452,0.001085787,0.00005305323,0.000007042021,0.00002119271,0.0002501016,0.00002681087,0.0003020256],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01729403,"threshold_uncertainty_score":0.03438669,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01854099472035756,"score_gpt":0.2700491640928593,"score_spread":0.2515081693725017,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}