{"id":"W2923364077","doi":"10.1021/acsomega.8b03638","title":"Synthesis of a 3,4-Disubstituted 1,8-Naphthalimide-Based DNA Intercalator for Direct Imaging of <i>Legionella pneumophila</i>","year":2019,"lang":"en","type":"article","venue":"ACS Omega","topic":"Molecular Sensors and Ion Detection","field":"Chemistry","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut interdisciplinaire d'innovation technologique; Université de Sherbrooke","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Networks of Centres of Excellence of Canada; Department of Biotechnology, Ministry of Science and Technology, India","keywords":"Chemistry; Intercalation (chemistry); Binding constant; Circular dichroism; Molecule; DNA; Fluorescence; Membrane; Covalent bond; Photochemistry; Combinatorial chemistry; Crystallography; Stereochemistry; Organic chemistry; Binding site; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001332071,0.0004288193,0.0002594707,0.0001487748,0.0001332068,0.0001172242,0.0004024298,0.0003194849,0.0009850913],"category_scores_gemma":[0.0001124138,0.0002048627,0.0002258606,0.0001757087,0.0001220753,0.0002213427,0.0001482208,0.0003273108,0.0006292294],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002691046,"about_ca_system_score_gemma":0.0003271888,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006742972,"about_ca_topic_score_gemma":0.001607806,"domain_scores_codex":[0.999927,0.000008778238,0.000008838839,0.00002166258,0.00002084679,0.00001280508],"domain_scores_gemma":[0.9999213,0.000007116784,0.0000218888,0.000008365987,0.00001909646,0.00002215351],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001589598,0.0000133243,0.00002788862,0.00004186198,0.000003367745,0.00002068342,0.000009406564,0.00008862368,0.9983321,0.00004776902,0.00001674351,0.001382351],"study_design_scores_gemma":[0.000005382041,0.0001589838,0.000378906,0.000002829361,0.000007322948,0.00007524358,0.000003398421,0.0005834014,0.9972512,0.000008305841,0.001519527,0.000005435656],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9445339,0.001930369,0.04716588,0.0001455713,0.00005220909,0.0003953539,0.0007432721,0.0004728591,0.004560479],"genre_scores_gemma":[0.9136724,0.002230611,0.0743008,0.0001113753,0.00001306263,0.0002283056,0.001211981,0.00009462159,0.008136857],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009850913,"threshold_uncertainty_score":0.003295422,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008306944905217701,"score_gpt":0.2177861756107431,"score_spread":0.2094792307055254,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}