{"id":"W2923364077","doi":"10.1021/acsomega.8b03638","title":"Synthesis of a 3,4-Disubstituted 1,8-Naphthalimide-Based DNA Intercalator for Direct Imaging of <i>Legionella pneumophila</i>","year":2019,"lang":"en","type":"article","venue":"ACS Omega","topic":"Molecular Sensors and Ion Detection","field":"Chemistry","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut interdisciplinaire d'innovation technologique; Université de Sherbrooke","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Research Chairs; Networks of Centres of Excellence of Canada; Department of Biotechnology, Ministry of Science and Technology, India","keywords":"Chemistry; Intercalation (chemistry); Binding constant; Circular dichroism; Molecule; DNA; Fluorescence; Membrane; Covalent bond; Photochemistry; Combinatorial chemistry; Crystallography; Stereochemistry; Organic chemistry; Binding site; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001278831,0.0001593031,0.0003445262,0.0001060909,0.0000296487,0.00001240774,0.0001792554,0.00008874853,0.0000220409],"category_scores_gemma":[0.0001757888,0.0001539982,0.0002265159,0.0001570188,0.000057622,0.00006815937,0.00003070773,0.00007537557,0.00001040205],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000322605,"about_ca_system_score_gemma":0.00003602436,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003638049,"about_ca_topic_score_gemma":0.000001669372,"domain_scores_codex":[0.9989566,0.00001693595,0.000371203,0.0002767292,0.0001877794,0.0001907898],"domain_scores_gemma":[0.9988895,0.0002272684,0.0002463032,0.0004441049,0.0001381027,0.00005470272],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001652947,0.00008640519,0.003652303,0.0004510702,0.00005184047,0.000002660429,0.00003199373,0.00009865552,0.9938775,0.00005580206,0.0002480101,0.001278415],"study_design_scores_gemma":[0.0005203998,0.0000288898,0.0001883314,0.0002246724,0.00005804536,0.00000574772,0.00004499987,0.001615509,0.9936481,0.00004356245,0.003461062,0.0001606516],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938932,0.0001143977,0.0002330648,0.0001052644,0.0001544538,0.0001494372,0.00006132691,0.00005026166,0.005238603],"genre_scores_gemma":[0.9992675,0.000009104776,0.0002679445,0.0000567261,0.00004443918,0.00003405515,0.00001577188,0.00003586165,0.0002686324],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005374274,"threshold_uncertainty_score":0.6279866,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008306944905217701,"score_gpt":0.2177861756107431,"score_spread":0.2094792307055254,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}