{"id":"W2923453543","doi":"10.1200/jco.18.02403","title":"Randomized Phase III Trial of Ibrutinib and Rituximab Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone in Non–Germinal Center B-Cell Diffuse Large B-Cell Lymphoma","year":2019,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Lymphoma Diagnosis and Treatment","field":"Medicine","cited_by":616,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sunnybrook Health Science Centre; BC Cancer Agency","funders":"National Cancer Institute","keywords":"Ibrutinib; Medicine; Vincristine; Internal medicine; Diffuse large B-cell lymphoma; Rituximab; Population; CHOP; Hazard ratio; Cyclophosphamide; Gastroenterology; Oncology; Lymphoma; Chemotherapy; Leukemia; Chronic lymphocytic leukemia; Confidence interval","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003015369,0.002075659,0.003737948,0.0004810592,0.000555341,0.001323169,0.001121573,0.001810721,0.006310601],"category_scores_gemma":[0.002644755,0.001028935,0.001735394,0.0005480698,0.001411749,0.001137903,0.0005455446,0.003664319,0.00129036],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009396152,"about_ca_system_score_gemma":0.001642758,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009092496,"about_ca_topic_score_gemma":0.002575145,"domain_scores_codex":[0.9986454,0.0008600018,0.00007602641,0.0001872613,0.00008085393,0.0001504416],"domain_scores_gemma":[0.998427,0.0004034057,0.0003242093,0.0001245557,0.000100214,0.0006205995],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9842079,0.004138749,0.0003978118,0.0002960666,0.0005878296,0.00003212665,0.0000297889,0.0002884593,0.001527602,0.00008810988,0.0006703798,0.007735217],"study_design_scores_gemma":[0.9809095,0.01777625,0.0004049088,0.00000968167,0.0001579287,0.00001603934,0.000006499854,0.0002159622,0.000125166,0.0000830712,0.0002899666,0.000004934681],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9669371,0.006890119,0.00185874,0.001742083,0.001909483,0.01365825,0.002510694,0.0002765249,0.004216887],"genre_scores_gemma":[0.9701118,0.003445728,0.002970035,0.002744548,0.0009496886,0.01236894,0.002293706,0.00005391231,0.005061657],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006310601,"threshold_uncertainty_score":0.02111107,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03015399178565479,"score_gpt":0.3882991784214436,"score_spread":0.3581451866357888,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}