{"id":"W2923503164","doi":"10.1038/s41598-018-37444-3","title":"Heterochromatic genome instability and neurodegeneration sharing similarities with Alzheimer’s disease in old Bmi1+/− mice","year":2019,"lang":"en","type":"article","venue":"Scientific Reports","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Douglas Mental Health University Institute; Université de Montréal; Hôpital Maisonneuve-Rosemont","funders":"Canadian Institutes of Health Research; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada; Government of Canada","keywords":"Neurodegeneration; BMI1; Biology; Heterochromatin; Genome instability; Alzheimer's disease; Chromatin; Genetically modified mouse; Genetics; Phenotype; Transgene; Disease; DNA damage; Gene; Medicine; Pathology; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005060801,0.0001302268,0.0001233185,0.0000661197,0.000080711,0.0001549917,0.00009150536,0.00004981055,0.00001749148],"category_scores_gemma":[0.00004366758,0.0001185578,0.00003308209,0.0001117751,0.00009878971,0.00002071946,0.0001482062,0.0000545012,0.000003244334],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001420578,"about_ca_system_score_gemma":0.00007475551,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002308652,"about_ca_topic_score_gemma":0.0001151253,"domain_scores_codex":[0.9984203,0.00003542433,0.0002691904,0.0008623442,0.0002064574,0.0002062676],"domain_scores_gemma":[0.9989523,0.000004107929,0.0001101112,0.0007735703,0.00005726406,0.0001025897],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002924366,0.00004598944,0.09206773,0.00005537426,0.00001111604,0.00005951326,0.00008732039,0.0007298835,0.9068042,0.00002364316,0.00002058731,0.00006537967],"study_design_scores_gemma":[0.0006689613,0.0002908854,0.1414247,0.00009785852,0.00007860416,0.0002153736,0.0001330176,0.004345391,0.8473424,0.002232484,0.002445015,0.0007252266],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983033,0.0004096615,0.00006531517,0.00003377861,0.0005910495,0.0004365045,0.000003381101,0.00001861972,0.0001383948],"genre_scores_gemma":[0.9986454,0.000004126235,0.000430916,0.0000572063,0.00002462724,0.0000267411,0.0001197096,0.00001631088,0.0006750252],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05946179,"threshold_uncertainty_score":0.4834648,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01110711365028328,"score_gpt":0.2211737312996401,"score_spread":0.2100666176493568,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}