{"id":"W2923519186","doi":"10.1111/apt.15214","title":"Early combined immunosuppression may be effective and safe in older patients with Crohn’s disease: post hoc analysis of REACT","year":2019,"lang":"en","type":"article","venue":"Alimentary Pharmacology & Therapeutics","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; University Hospital; Robarts Clinical Trials","funders":"Crohn's and Colitis Foundation; National Institute of Diabetes and Digestive and Kidney Diseases; American College of Gastroenterology","keywords":"Medicine; Immunosuppression; Crohn's disease; Internal medicine; Post-hoc analysis; Hazard ratio; Adverse effect; Surgery; Relative risk; Disease; Confidence interval","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01805216,0.0009128842,0.002340253,0.0003331317,0.0002350159,0.0007471428,0.0007373755,0.0006833089,0.004344192],"category_scores_gemma":[0.02042816,0.0003335874,0.006728026,0.0003432707,0.0007918095,0.0008648204,0.0007515036,0.001453878,0.0002182002],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005888357,"about_ca_system_score_gemma":0.0009500409,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005101621,"about_ca_topic_score_gemma":0.0005819682,"domain_scores_codex":[0.9846697,0.01244222,0.0006733408,0.0009800831,0.0005834791,0.0006511577],"domain_scores_gemma":[0.9684448,0.02416127,0.003505314,0.002579628,0.0006488645,0.0006601312],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.9411413,0.001536003,0.03060035,0.0009481098,0.009905886,0.0001382788,0.0001574327,0.002036863,0.001178449,0.0003091654,0.0005904399,0.01145769],"study_design_scores_gemma":[0.244086,0.4030351,0.2759673,0.000281044,0.04069709,0.000411866,0.0005218539,0.02301929,0.005268523,0.001658626,0.004881541,0.0001717686],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960687,0.0007838415,0.001315432,0.000107771,0.0001317176,0.000553478,0.0004365303,0.00001961343,0.0005828928],"genre_scores_gemma":[0.9969139,0.000135515,0.00117529,0.0001145693,0.00009026951,0.0006902565,0.0004090126,0.00001394097,0.0004571476],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01805216,"threshold_uncertainty_score":0.09547007,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003753921309356458,"score_gpt":0.2496591662621861,"score_spread":0.2459052449528296,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}