{"id":"W2923565608","doi":"10.1002/slct.201803549","title":"Synthesis, Structure Elucidation, Homology Modeling and Antifilarial Activity of 7‐Benzamidocoumarin Derivatives","year":2019,"lang":"en","type":"article","venue":"ChemistrySelect","topic":"Parasitic Diseases Research and Treatment","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Banaras Hindu University; Canadian Institute of Steel Construction","keywords":"Brugia malayi; Onchocerca volvulus; In vitro; Stereochemistry; Homology modeling; Hydrogen bond; Structure–activity relationship; Chemistry; Enzyme; Active site; Biology; Biochemistry; Helminths; Onchocerciasis; Filariasis; Immunology; Molecule; Organic chemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004496298,0.0001106038,0.0002624977,0.00003471926,0.0000292278,0.000009145273,0.00004829193,0.00007443084,0.0004333005],"category_scores_gemma":[0.0003229974,0.00009356197,0.00004494517,0.00008944891,0.00006931175,0.00004591408,0.00002979338,0.0001013346,0.000003486124],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004061269,"about_ca_system_score_gemma":0.0002207553,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003149534,"about_ca_topic_score_gemma":0.000001517427,"domain_scores_codex":[0.9992856,0.00002215712,0.0001118071,0.000239105,0.0001558355,0.0001854313],"domain_scores_gemma":[0.9994228,0.00008865415,0.00004587491,0.0002127967,0.00009158519,0.0001383049],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005001642,0.0001427299,0.04173743,0.00031939,0.0002125654,0.00001151136,0.00003441836,0.00003287386,0.9539187,0.00002536395,0.00003397759,0.003030892],"study_design_scores_gemma":[0.0009669693,0.00009225099,0.01959579,0.00005784094,0.0000869572,0.00004512735,0.00002349315,0.00458916,0.974264,0.000180363,0.00001409303,0.00008401537],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997349,0.0002039407,0.0002688852,0.00007066785,0.0000154866,0.0002112811,0.00004094132,0.00001639879,0.001823452],"genre_scores_gemma":[0.9994042,0.00003815275,0.0002716642,0.00001030629,0.00003900381,0.00001180935,0.00004453448,0.000009745848,0.0001705942],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02214163,"threshold_uncertainty_score":0.4744337,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01281345559247605,"score_gpt":0.2955776350938461,"score_spread":0.2827641795013701,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}