{"id":"W2923565608","doi":"10.1002/slct.201803549","title":"Synthesis, Structure Elucidation, Homology Modeling and Antifilarial Activity of 7‐Benzamidocoumarin Derivatives","year":2019,"lang":"en","type":"article","venue":"ChemistrySelect","topic":"Parasitic Diseases Research and Treatment","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Banaras Hindu University; Canadian Institute of Steel Construction","keywords":"Brugia malayi; Onchocerca volvulus; In vitro; Stereochemistry; Homology modeling; Hydrogen bond; Structure–activity relationship; Chemistry; Enzyme; Active site; Biology; Biochemistry; Helminths; Onchocerciasis; Filariasis; Immunology; Molecule; Organic chemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000958297,0.000324101,0.0003123191,0.000172659,0.0001616834,0.0002067043,0.0003801285,0.0001849965,0.002222471],"category_scores_gemma":[0.0001060194,0.0001190237,0.0002323525,0.000219211,0.0001065693,0.0001553508,0.0001317207,0.0003827527,0.0005184858],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002824932,"about_ca_system_score_gemma":0.0003968821,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001713271,"about_ca_topic_score_gemma":0.001829099,"domain_scores_codex":[0.9999603,0.000006292482,0.000001747168,0.000006172445,0.00001268485,0.00001284209],"domain_scores_gemma":[0.9999653,0.000005302922,0.00001039812,0.00000301314,0.000007721911,0.000008237056],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005410147,0.000477107,0.001025913,0.001044177,0.00009578654,0.001096567,0.000164119,0.05823047,0.9045913,0.004804939,0.0009898692,0.02693882],"study_design_scores_gemma":[0.000317377,0.003118473,0.003543884,0.0000896033,0.0001512452,0.0006436234,0.0001633632,0.04140507,0.9102669,0.000612481,0.03960973,0.00007814488],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9688384,0.008873237,0.01294281,0.0002115383,0.00004323282,0.0001602382,0.001206703,0.0001739773,0.007549908],"genre_scores_gemma":[0.9818612,0.005796918,0.008183553,0.00002885516,0.000007672977,0.00006492107,0.0009784263,0.00001689496,0.003061487],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002222471,"threshold_uncertainty_score":0.007434905,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01281345559247605,"score_gpt":0.2955776350938461,"score_spread":0.2827641795013701,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}