{"id":"W2923713236","doi":"10.1080/19420862.2019.1595307","title":"Detection and quantification of free sulfhydryls in monoclonal antibodies using maleimide labeling and mass spectrometry","year":2019,"lang":"en","type":"article","venue":"mAbs","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada","funders":"","keywords":"Chemistry; Maleimide; Cysteine; Chromatography; Mass spectrometry; Reagent; Monoclonal antibody; Biochemistry; Antibody; Enzyme; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001627412,0.001631054,0.0006583805,0.00149839,0.0005039943,0.0006663355,0.0009638637,0.0008953951,0.001237278],"category_scores_gemma":[0.001189177,0.0006155825,0.0006574205,0.000920503,0.0007149347,0.0006535626,0.0008797365,0.00168468,0.0007926588],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007732302,"about_ca_system_score_gemma":0.0006282039,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007042526,"about_ca_topic_score_gemma":0.001832288,"domain_scores_codex":[0.9981205,0.0002964539,0.0001110805,0.0004675284,0.0008420098,0.0001623123],"domain_scores_gemma":[0.9990344,0.0002023701,0.0001994129,0.0001351049,0.0003341254,0.00009462491],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002857046,0.00001476759,0.000153076,0.00007380562,0.00001444431,0.00002396013,0.00002609635,0.00005558446,0.9968347,0.0001527116,0.00007570315,0.002546561],"study_design_scores_gemma":[0.000008967174,0.0001098897,0.001455788,0.00001326261,0.00002241168,0.0001641947,0.00001482009,0.001594186,0.9936334,0.0001598255,0.002809668,0.00001351401],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.4162203,0.006665581,0.5668082,0.0003090486,0.0002582959,0.0007557693,0.001295692,0.002021211,0.005665943],"genre_scores_gemma":[0.3989063,0.008897379,0.5757159,0.000446464,0.000143203,0.002216418,0.002797065,0.0004609494,0.01041637],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.001631054,"threshold_uncertainty_score":0.008606672,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03446249204436033,"score_gpt":0.3091059037930905,"score_spread":0.2746434117487302,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}