{"id":"W2923859939","doi":"10.1101/586339","title":"GWAS of 19,629 individuals identifies novel genetic variants for regional brain volumes and refines their genetic co-architecture with cognitive and mental health traits","year":2019,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"NIH Blueprint for Neuroscience Research; National Institute on Drug Abuse; Canadian Institutes of Health Research; National Institutes of Health; Cancer Prevention and Research Institute of Texas; Genentech; IXICO; Servier; Eisai; Northern California Institute for Research and Education; University of California, San Diego; Pfizer; Biogen; BioClinica; McDonnell Center for Systems Neuroscience; F. Hoffmann-La Roche; Synarc; University of Southern California; Medpace; Eli Lilly and Company; Bristol-Myers Squibb; Novartis Pharmaceuticals Corporation; Meso Scale Diagnostics; Cancer Research Institute; Foundation for the National Institutes of Health","keywords":"Genome-wide association study; Genetic architecture; Pleiotropy; Single-nucleotide polymorphism; Biology; Genetic association; Genetics; Locus (genetics); Biobank; Quantitative trait locus; Phenotype; Gene; Genotype","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009862854,0.000503326,0.0005886192,0.0008934107,0.0005378728,0.0006760146,0.0003272949,0.0004240757,0.003788908],"category_scores_gemma":[0.003142353,0.0002872252,0.0007087536,0.001604163,0.0003380561,0.0002461854,0.0007066911,0.000419077,0.0003471386],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002093958,"about_ca_system_score_gemma":0.0002878348,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006033422,"about_ca_topic_score_gemma":0.008738298,"domain_scores_codex":[0.9990001,0.0002950593,0.0001140265,0.0003632519,0.0001465313,0.00008111996],"domain_scores_gemma":[0.9987652,0.0005232768,0.0003098289,0.0001908002,0.0001213055,0.00008963602],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001213801,0.00007971178,0.9471149,0.0001494823,0.001704806,0.002062074,0.0003812765,0.0005594066,0.0303354,0.000448886,0.001251337,0.01469895],"study_design_scores_gemma":[0.00009548781,0.00008673958,0.9937879,0.00003367095,0.0004822251,0.001160974,0.00009198285,0.0006174957,0.001800994,0.0002748097,0.001552139,0.00001554606],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921393,0.001324387,0.003210715,0.0001738844,0.00003195828,0.00002497321,0.002381814,0.00004229087,0.0006707786],"genre_scores_gemma":[0.996168,0.0002931722,0.00187499,0.0000752515,0.00001737782,0.00002224169,0.001123055,0.00001464148,0.000411359],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006033422,"threshold_uncertainty_score":0.01267517,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01594976865133442,"score_gpt":0.2526119484292303,"score_spread":0.2366621797778959,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}