{"id":"W2923871137","doi":"10.6004/jnccn.2018.7184","title":"CLO19-033: Afatinib Followed by Osimertinib in EGFR Mutation-Positive (EGFRm+) Advanced NSCLC: Subgroup Analyses of the GioTag Study by ECOG PS, Age, and Ethnicity","year":2019,"lang":"en","type":"article","venue":"Journal of the National Comprehensive Cancer Network","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Afatinib; Medicine; Osimertinib; T790M; Discontinuation; Internal medicine; Oncology; Clinical trial; Erlotinib; Cancer; Epidermal growth factor receptor; Gefitinib","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002003838,0.0002092348,0.0005407053,0.00008646638,0.00014781,0.00002163857,0.00021556,0.00006989429,0.00005309702],"category_scores_gemma":[0.0001209186,0.0001248107,0.0002284566,0.0006466577,0.0001122682,0.0001549065,0.0000726876,0.0003969788,0.000001096392],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004433856,"about_ca_system_score_gemma":0.0003490703,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002590312,"about_ca_topic_score_gemma":0.0001761895,"domain_scores_codex":[0.9977677,0.0002877257,0.0006973693,0.0002267376,0.0008131153,0.0002073143],"domain_scores_gemma":[0.9970888,0.0006019642,0.0009302208,0.0001661727,0.001131351,0.00008145536],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005124923,0.002856991,0.6336245,0.0001891187,0.007518213,0.0000605824,0.007023864,0.1356918,0.05832693,0.0002007474,0.1418524,0.007529923],"study_design_scores_gemma":[0.01103483,0.0008209223,0.9780108,0.0008059623,0.001021309,0.00003904524,0.00127921,0.00050281,0.002945309,0.0004538605,0.002863372,0.000222562],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9854713,0.009972793,0.00003088587,0.002084817,0.0007393633,0.001146144,0.0001037043,0.000005280106,0.0004457189],"genre_scores_gemma":[0.9971284,0.0002847994,0.0001708051,0.001630175,0.0001965893,0.00002984996,0.00001833585,0.00002107062,0.0005199351],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3443863,"threshold_uncertainty_score":0.5089631,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03281158859745364,"score_gpt":0.3887960014115104,"score_spread":0.3559844128140567,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}