{"id":"W2923871137","doi":"10.6004/jnccn.2018.7184","title":"CLO19-033: Afatinib Followed by Osimertinib in EGFR Mutation-Positive (EGFRm+) Advanced NSCLC: Subgroup Analyses of the GioTag Study by ECOG PS, Age, and Ethnicity","year":2019,"lang":"en","type":"article","venue":"Journal of the National Comprehensive Cancer Network","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Afatinib; Medicine; Osimertinib; T790M; Discontinuation; Internal medicine; Oncology; Clinical trial; Erlotinib; Cancer; Epidermal growth factor receptor; Gefitinib","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.006371203,0.0009697423,0.002622235,0.001099523,0.0003419956,0.001433078,0.0008933196,0.001177312,0.001990247],"category_scores_gemma":[0.006430091,0.0003966497,0.01032443,0.001907895,0.0004923473,0.0009668054,0.0009202623,0.001426993,0.0002646135],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007998964,"about_ca_system_score_gemma":0.001167887,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002348011,"about_ca_topic_score_gemma":0.006326035,"domain_scores_codex":[0.9952172,0.00226855,0.0008601488,0.0007291701,0.0004608372,0.0004642217],"domain_scores_gemma":[0.9965479,0.001403499,0.00108809,0.0004700887,0.000205045,0.0002854815],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"observational","study_design_scores_codex":[0.4971644,0.0007645188,0.3722789,0.003143226,0.09338564,0.0006836443,0.0003823243,0.001528365,0.003620692,0.0003592048,0.003106375,0.0235827],"study_design_scores_gemma":[0.09140161,0.04013336,0.719393,0.00078404,0.1291666,0.001425429,0.001288754,0.003921565,0.002203844,0.002022213,0.008045236,0.0002142674],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.983507,0.01135289,0.0003142594,0.0002959007,0.0001148066,0.000447541,0.00278084,0.0000197524,0.00116703],"genre_scores_gemma":[0.9958549,0.0008767367,0.0002324037,0.0002902197,0.00009664295,0.0003553656,0.002035998,0.00001565405,0.0002421145],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006371203,"threshold_uncertainty_score":0.03369451,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03281158859745364,"score_gpt":0.3887960014115104,"score_spread":0.3559844128140567,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}