{"id":"W2923942876","doi":"10.1016/j.jcf.2019.03.005","title":"A two-center analysis of hyperpolarized 129Xe lung MRI in stable pediatric cystic fibrosis: Potential as a biomarker for multi-site trials","year":2019,"lang":"en","type":"article","venue":"Journal of Cystic Fibrosis","topic":"Atomic and Subatomic Physics Research","field":"Physics and Astronomy","cited_by":58,"is_retracted":false,"has_abstract":false,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"National Heart, Lung, and Blood Institute; National Institutes of Health; Mitacs; Canadian Institutes of Health Research; Hospital for Sick Children; Natural Sciences and Engineering Research Council of Canada","keywords":"Cystic fibrosis; Medicine; Biomarker; Lung; Radiology; Magnetic resonance imaging; Internal medicine; Nuclear medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002233591,0.0003010702,0.001781399,0.001098021,0.0000738523,0.0001080229,0.0004135553,0.000100202,0.0006659604],"category_scores_gemma":[0.000164779,0.0002481239,0.001388848,0.001258585,0.00004828145,0.0003810314,0.0001140051,0.0003217042,0.00002814871],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00017804,"about_ca_system_score_gemma":0.0005793783,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004594673,"about_ca_topic_score_gemma":0.000004338204,"domain_scores_codex":[0.9963058,0.0004382767,0.001749394,0.0003347011,0.0006158088,0.0005559693],"domain_scores_gemma":[0.9966017,0.001112025,0.00129955,0.0003492077,0.0004316663,0.0002058263],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.007445069,0.001774233,0.7177251,0.0004770845,0.00733576,0.00001202277,0.00118779,0.00656255,0.2521266,0.0006911388,0.001682983,0.002979693],"study_design_scores_gemma":[0.0265333,0.0003588434,0.05225755,0.0003188284,0.007441519,0.000007304006,0.001329961,0.9062942,0.003238602,0.001281907,0.0002587466,0.0006792633],"study_design_candidate":"simulation_or_modeling","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8354875,0.000341011,0.1625417,0.00004123823,0.0002596529,0.0006086509,0.0005679617,0.000005932985,0.0001463715],"genre_scores_gemma":[0.990042,0.00002023181,0.009256033,0.00001415097,0.0002858458,0.0000243621,0.00007853088,0.00003918969,0.0002396078],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8997316,"threshold_uncertainty_score":0.9999971,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02421949486066264,"score_gpt":0.3306388426703782,"score_spread":0.3064193478097155,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}