{"id":"W2923997129","doi":"10.1093/ibd/izz039","title":"The Inflammatory Bowel Disease Drug Azathioprine Induces Autophagy via mTORC1 and the Unfolded Protein Response Sensor PERK","year":2019,"lang":"en","type":"article","venue":"Inflammatory Bowel Diseases","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Crohn's and Colitis UK; Hospital for Sick Children; Hebrew University of Jerusalem; Edinburgh Napier University","keywords":"Autophagy; ATG16L1; Azathioprine; mTORC1; PI3K/AKT/mTOR pathway; ATG5; Biology; Cancer research; Medicine; Signal transduction; Cell biology; Apoptosis; Disease; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001287586,0.0002033894,0.0002699364,0.0002148158,0.0001057682,0.0002686636,0.00008165042,0.0002070191,0.0008844277],"category_scores_gemma":[0.0001130797,0.000088093,0.0001864564,0.0001209016,0.0001487311,0.0001120885,0.0001241748,0.0002869706,0.0002502278],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002526336,"about_ca_system_score_gemma":0.0001136389,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000139811,"about_ca_topic_score_gemma":0.0002911149,"domain_scores_codex":[0.9998915,0.00002332371,0.00001425635,0.00002380478,0.00002912229,0.00001791146],"domain_scores_gemma":[0.9999118,0.00001323546,0.0000437245,0.000006596453,0.00001115983,0.0000134312],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000480033,0.00004469804,0.001444175,0.0002036402,0.00002315589,0.0001092972,0.00001228826,0.00009051228,0.9908386,0.00005375563,0.0001278854,0.00657202],"study_design_scores_gemma":[0.0001139961,0.002003435,0.06982195,0.00006143456,0.0001266201,0.001539671,0.00004768539,0.001633458,0.9171305,0.0001387537,0.007371139,0.0000112976],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9837123,0.01308196,0.0009573611,0.0002128377,0.00004428993,0.00002724754,0.000316383,0.00009335118,0.001554207],"genre_scores_gemma":[0.994873,0.002884638,0.001068676,0.00008619978,0.00002404008,0.00002657774,0.0003145654,0.00000808267,0.0007141765],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008844277,"threshold_uncertainty_score":0.002958655,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005359494841335297,"score_gpt":0.2304719910257391,"score_spread":0.2251124961844038,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}