{"id":"W2924099336","doi":"10.1038/s41467-019-09299-3","title":"The conserved NxNNWHW motif in Aha-type co-chaperones modulates the kinetics of Hsp90 ATPase stimulation","year":2019,"lang":"en","type":"article","venue":"Nature Communications","topic":"Heat shock proteins research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada; Alberta Cancer Foundation; Canadian Institutes of Health Research; Alberta Innovates; National Institutes of Health; University of Alberta","keywords":"Hsp90; Chaperone (clinical); ATPase; Nucleotide; Cell biology; Co-chaperone; Yeast; Biochemistry; Chemistry; Protein folding; Saccharomyces cerevisiae; Biology; Enzyme; Heat shock protein; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007799164,0.0001049101,0.0001472797,0.00004280041,0.00006579283,0.0001517233,0.0001138893,0.0001267992,0.000706454],"category_scores_gemma":[0.0001298125,0.00006635518,0.0001169704,0.00005299032,0.0001227475,0.0001362498,0.000123568,0.0002584929,0.0002669536],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001359653,"about_ca_system_score_gemma":0.00008033912,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002440033,"about_ca_topic_score_gemma":0.0003424264,"domain_scores_codex":[0.9999338,0.00001395853,0.000005594719,0.00001497453,0.00001568337,0.00001585823],"domain_scores_gemma":[0.9999102,0.00001658744,0.00002465829,0.00001214848,0.000008323684,0.00002801915],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008645738,0.00000694322,0.0001349201,0.000005280683,0.000001435813,0.00001583011,0.000002818046,0.00002389462,0.9993135,0.00002168179,0.00001070527,0.000376597],"study_design_scores_gemma":[0.00001177296,0.0001565262,0.01085831,0.00000282446,0.000005124499,0.0001779677,0.00001803107,0.001115866,0.9869141,0.00003948862,0.0006945665,0.00000539862],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984795,0.0003277462,0.0007933382,0.00002737616,0.00001103304,0.000003980312,0.00005210901,0.00001717863,0.0002877473],"genre_scores_gemma":[0.9991917,0.00007070135,0.0002771667,0.00001571729,0.000003003293,0.000003492603,0.00006272711,0.000005397314,0.0003700488],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000706454,"threshold_uncertainty_score":0.002363384,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0240023462232143,"score_gpt":0.3396577631552696,"score_spread":0.3156554169320553,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}