{"id":"W2924121933","doi":"10.24820/ark.5550190.p010.783","title":"Deciphering the conformation of C-linked α-D-mannopyranosides and their application toward the synthesis of low nanomolar E. coli FimH ligands","year":2018,"lang":"en","type":"article","venue":"ARKIVOC","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Armand Frappier Museum; BioPhage Pharma (Canada); Institut National de la Recherche Scientifique; Université du Québec à Montréal","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Stereochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009912276,0.0001514313,0.00008164956,0.00006898368,0.00008391774,0.0001687443,0.0001109091,0.0001441338,0.0005797844],"category_scores_gemma":[0.0001570433,0.00007411595,0.00007866111,0.0001313807,0.0001275409,0.0001462081,0.00007537202,0.0004176843,0.0001849102],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001861656,"about_ca_system_score_gemma":0.0001624394,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004754777,"about_ca_topic_score_gemma":0.0007376043,"domain_scores_codex":[0.9999692,0.000007296715,0.000001756646,0.000005608385,0.000006149545,0.000009877135],"domain_scores_gemma":[0.9999535,0.00001204829,0.00001295172,0.000006507375,0.000005871713,0.000009049082],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005442763,0.000008001797,0.0001101863,0.00001694203,0.000001582711,0.0000384679,0.00001993723,0.0003886573,0.9973859,0.0002103631,0.00001127141,0.001754263],"study_design_scores_gemma":[0.00000347433,0.00008406342,0.0003837692,0.000001895616,0.000003074513,0.00005761,0.00001286563,0.0005840015,0.9979953,0.00005693958,0.0008145869,0.00000244281],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941663,0.0003216006,0.004230901,0.00004565082,0.000004229304,0.00001279081,0.00008386869,0.00002055322,0.001114205],"genre_scores_gemma":[0.9930553,0.0003827904,0.005812149,0.00001999467,0.000001733267,0.000008924685,0.0001177063,0.000007679434,0.0005936913],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005797844,"threshold_uncertainty_score":0.001939535,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01001477626079264,"score_gpt":0.2085479829900532,"score_spread":0.1985332067292605,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}