{"id":"W2924170852","doi":"10.1126/science.aan0925","title":"Cell competition during reprogramming gives rise to dominant clones","year":2019,"lang":"en","type":"article","venue":"Science","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":124,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Reprogramming; Neural crest; Biology; Embryonic stem cell; Stem cell; Cell biology; Cell type; Developmental biology; Population; Cell; Neuroscience; Perspective (graphical); Genetics; Embryo; Sociology; Computer science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004375123,0.00007012942,0.00006473689,0.00007700174,0.0001422123,0.00005700466,0.0003592819,0.00003080165,0.00002184924],"category_scores_gemma":[0.00005335465,0.00006333582,0.00003050107,0.0002686373,0.0001496472,0.000008309727,0.000319721,0.00004845806,0.0002754202],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002169382,"about_ca_system_score_gemma":0.00006945249,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001134908,"about_ca_topic_score_gemma":0.000004360902,"domain_scores_codex":[0.9987969,0.00002238711,0.00009371312,0.0004682083,0.000281078,0.0003377339],"domain_scores_gemma":[0.9993729,0.000005166887,0.00002915528,0.0003901416,0.00008199023,0.000120658],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002464175,0.00002171835,0.003843795,0.0000218315,9.019975e-7,0.000002719099,0.00004789848,0.00004723351,0.9953911,0.00001296103,0.00002217793,0.0005630555],"study_design_scores_gemma":[0.0001850555,0.0001211993,0.0179872,0.00001523396,9.558435e-7,0.000007433155,0.00009962084,0.00006186124,0.9730439,0.000008349435,0.008369702,0.00009944518],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970003,0.0002155583,0.0002195424,0.0001073505,0.0001478567,0.000235393,0.000002157405,0.000008013782,0.002063766],"genre_scores_gemma":[0.9956609,0.00004061916,0.001275644,0.00002645567,0.00004876883,0.0000106727,0.00000306414,0.000006432078,0.002927467],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02234713,"threshold_uncertainty_score":0.3540061,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006655339394331635,"score_gpt":0.262264905844495,"score_spread":0.2556095664501633,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}