{"id":"W2924170852","doi":"10.1126/science.aan0925","title":"Cell competition during reprogramming gives rise to dominant clones","year":2019,"lang":"en","type":"article","venue":"Science","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":124,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Reprogramming; Neural crest; Biology; Embryonic stem cell; Stem cell; Cell biology; Cell type; Developmental biology; Population; Cell; Neuroscience; Perspective (graphical); Genetics; Embryo; Sociology; Computer science","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004045424,0.0002141475,0.0003261972,0.0001735054,0.0002118296,0.0006341309,0.0003581244,0.0003073695,0.00103694],"category_scores_gemma":[0.0007188873,0.0002271451,0.0002200774,0.0001475866,0.0002745554,0.0003037673,0.0006007817,0.0004282588,0.0002743746],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005309251,"about_ca_system_score_gemma":0.0002550285,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006437669,"about_ca_topic_score_gemma":0.001305581,"domain_scores_codex":[0.9997002,0.00003648869,0.00001733888,0.00008083396,0.0001054677,0.00005982145],"domain_scores_gemma":[0.9995426,0.0002040261,0.00009727688,0.00005100574,0.00004797471,0.00005716999],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007459684,0.00001943864,0.002291012,0.00003837339,0.00001512722,0.000209452,0.0001315438,0.003781172,0.9778005,0.007866187,0.0001253357,0.00764716],"study_design_scores_gemma":[0.0000535949,0.0003180418,0.01088475,0.00001637546,0.0000823672,0.001542787,0.0001293709,0.1041174,0.8697904,0.005414632,0.007614214,0.00003621578],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9458102,0.0004314444,0.04939587,0.00007155407,0.00001517491,0.00001930425,0.00006807523,0.000110601,0.004077791],"genre_scores_gemma":[0.9930303,0.0001438726,0.004974571,0.00005020179,0.000004619029,0.00002012566,0.00005908231,0.00004137228,0.001675856],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00103694,"threshold_uncertainty_score":0.003852189,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006655339394331635,"score_gpt":0.262264905844495,"score_spread":0.2556095664501633,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}