{"id":"W2924350756","doi":"","title":"Pharmacological nonsense suppression therapy in the Rpe65-/- mouse model of Leber congenital amaurosis reverses the retinal deficits in vivo","year":2018,"lang":"en","type":"article","venue":"Investigative Ophthalmology & Visual Science","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan; University of British Columbia","funders":"","keywords":"RPE65; Nonsense; Medicine; Retinal; In vivo; Ophthalmology; Biology; Retinal pigment epithelium","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["sts"],"consensus_categories":[],"category_scores_codex":[0.001059905,0.0001755748,0.0001590795,0.00008507072,0.0002105308,0.00002244817,0.0006439236,0.0001225996,0.00005084436],"category_scores_gemma":[0.0004417839,0.0001012981,0.00004795919,0.0005071072,0.005891693,0.00001953162,0.0002007575,0.0001829573,0.000004848384],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001848344,"about_ca_system_score_gemma":0.0002821722,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008076311,"about_ca_topic_score_gemma":0.0000285821,"domain_scores_codex":[0.9982139,0.0003975983,0.0002787593,0.0004510594,0.0002828738,0.0003757988],"domain_scores_gemma":[0.9993654,0.0001054697,0.0001239933,0.0001884411,0.0001530976,0.00006352587],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000264616,0.0001220881,0.0412847,0.000001769473,0.00000671202,0.00001009824,0.001087337,0.00006626084,0.9568305,0.00004430335,0.0002370945,0.00004455096],"study_design_scores_gemma":[0.0004970254,0.0008392426,0.0312902,0.00001023987,0.000005479869,0.00003973954,0.0007213575,0.0009660801,0.964811,0.0006304741,0.00004382813,0.000145292],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972823,0.00007106348,0.000004702577,0.000469236,0.00007854868,0.0003364951,0.000009039307,0.000003653855,0.001744909],"genre_scores_gemma":[0.9986805,0.00005031642,0.0003539587,0.0006675394,0.00003125668,0.00004408337,0.000004013603,0.000007222108,0.0001611471],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009994491,"threshold_uncertainty_score":0.9968137,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05012516317303656,"score_gpt":0.3407055445097276,"score_spread":0.290580381336691,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}