{"id":"W2924415036","doi":"10.1186/s40478-018-0654-6","title":"Optic nerve thinning and neurosensory retinal degeneration in the rTg4510 mouse model of frontotemporal dementia","year":2019,"lang":"en","type":"article","venue":"Acta Neuropathologica Communications","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"Medical Research Council; Biotechnology and Biological Sciences Research Council; UK Regenerative Medicine Platform; Moorfields Eye Hospital NHS Foundation Trust; Queen's University; Simon Fraser University; Brain Research Trust; Wolfson Foundation; Alzheimer's Society; National Institute for Health and Care Research; Queen's University Belfast; University College London; Engineering and Physical Sciences Research Council; AstraZeneca; Eli Lilly and Company","keywords":"Retina; Frontotemporal dementia; Pathology; Retinal; Optic nerve; Inner plexiform layer; Inner nuclear layer; Medicine; Retinal ganglion cell; Neuroscience; Dementia; Ophthalmology; Psychology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005189854,0.001689933,0.0004698265,0.00262541,0.0006054043,0.0006523314,0.0004919598,0.001568461,0.003017474],"category_scores_gemma":[0.0001784247,0.0007514847,0.000880999,0.0006079507,0.0007099569,0.0004824102,0.0004857391,0.0009919343,0.0008027118],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009689651,"about_ca_system_score_gemma":0.0004153245,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004326783,"about_ca_topic_score_gemma":0.007522829,"domain_scores_codex":[0.9994466,0.00006074414,0.00008456611,0.0001685611,0.0001458711,0.00009365463],"domain_scores_gemma":[0.9996223,0.00002021449,0.0001701782,0.00003052154,0.0000314947,0.000125295],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001085574,0.0004728546,0.001642879,0.0001298534,0.00006019747,0.001420818,0.000259243,0.0001747916,0.9921954,0.0003029011,0.000291173,0.001964384],"study_design_scores_gemma":[0.001126005,0.007619096,0.1658067,0.0003646475,0.0005708105,0.01916255,0.0009277503,0.006326515,0.7838551,0.0009564693,0.01316526,0.0001190655],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9938613,0.0008732189,0.00112087,0.0001540944,0.00004573765,0.0001206738,0.001740486,0.0001957653,0.001887835],"genre_scores_gemma":[0.979872,0.001507196,0.003927114,0.0002351503,0.00002309244,0.0003476083,0.002677754,0.000100275,0.01130972],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004326783,"threshold_uncertainty_score":0.01009446,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07988784986295118,"score_gpt":0.320634436416373,"score_spread":0.2407465865534218,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}