{"id":"W2924442144","doi":"10.3390/molecules24061189","title":"Cardiac-Specific Cre Induces Age-Dependent Dilated Cardiomyopathy (DCM) in Mice","year":2019,"lang":"en","type":"article","venue":"Molecules","topic":"Cardiomyopathy and Myosin Studies","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Canadian Institutes of Health Research","keywords":"Dilated cardiomyopathy; Cre recombinase; Transgene; Phenotype; Cardiomyopathy; Biology; Genetically modified mouse; Fibrosis; Downregulation and upregulation; Gene; Heart failure; Medicine; Genetics; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001082898,0.0007695239,0.0005854727,0.001370166,0.000443259,0.0004452418,0.0007020543,0.001096113,0.005190343],"category_scores_gemma":[0.0003577655,0.000413777,0.0007065988,0.0004469644,0.0005830006,0.0006694669,0.0005336926,0.001752877,0.001436086],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003154126,"about_ca_system_score_gemma":0.0003468673,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002709065,"about_ca_topic_score_gemma":0.0006436863,"domain_scores_codex":[0.9991967,0.0001472739,0.000130742,0.0002169186,0.000171887,0.0001363912],"domain_scores_gemma":[0.9994326,0.00007985545,0.000200571,0.00008585364,0.0000577803,0.0001433927],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000149319,0.0001424812,0.0002156424,0.0000907476,0.00001056186,0.0001879565,0.00005952372,0.00003556436,0.9967322,0.000467197,0.0001817724,0.001726958],"study_design_scores_gemma":[0.0001542187,0.002544526,0.007783439,0.0001193915,0.00008503439,0.00249288,0.0001270616,0.0008300633,0.9650513,0.0003684645,0.02041676,0.00002682353],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9119004,0.005312441,0.06164394,0.001108557,0.0007985212,0.001508904,0.004706046,0.001586522,0.01143469],"genre_scores_gemma":[0.904181,0.007497795,0.04384205,0.00118489,0.0002384977,0.002264761,0.006963506,0.0006313088,0.03319614],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005190343,"threshold_uncertainty_score":0.01736343,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0145671260314537,"score_gpt":0.242571474234768,"score_spread":0.2280043482033143,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}