{"id":"W2924517174","doi":"10.3390/cancers11030416","title":"Tailoring Ovarian Cancer Treatment: Implications of BRCA1/2 Mutations","year":2019,"lang":"en","type":"review","venue":"Cancers","topic":"Ovarian cancer diagnosis and treatment","field":"Medicine","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Ovarian cancer; Homologous recombination; Cancer research; Olaparib; Germline mutation; DNA repair; Mutation; BRCA2 Protein; PARP inhibitor; Cancer; DNA damage; Biology; Poly ADP ribose polymerase; Genome instability; Germline; Serous fluid; Gene; Medicine; Genetics; Polymerase; DNA; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00036102,0.0004339828,0.0009708229,0.001550353,0.0001424553,0.0006255893,0.0005426761,0.0006219859,0.003178781],"category_scores_gemma":[0.0006849741,0.0001454228,0.000408091,0.001325397,0.0002042982,0.0006793151,0.0004741035,0.001076276,0.001252042],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004120315,"about_ca_system_score_gemma":0.0005926602,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008229092,"about_ca_topic_score_gemma":0.001640655,"domain_scores_codex":[0.9998761,0.00002647991,0.00002008218,0.0000245977,0.00004176626,0.00001105615],"domain_scores_gemma":[0.9997844,0.0001176693,0.00003104737,0.000005233855,0.00004613792,0.00001550567],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005783446,0.0000476893,0.0001513269,0.01784214,0.00008184889,0.0001198543,0.00003671378,0.0003431394,0.0009166192,0.001748732,0.01761969,0.9610344],"study_design_scores_gemma":[0.00002369467,0.0001269133,0.001073346,0.007024588,0.000180071,0.001226393,0.00005802507,0.0001324001,0.0004144175,0.001510703,0.9882145,0.00001482085],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001287933,0.9988481,0.00008040494,0.0001823095,0.00008565136,0.000003900137,0.00002229141,0.000004871843,0.0006437007],"genre_scores_gemma":[0.0007216751,0.998449,0.0001446215,0.0001591017,0.00007678675,0.00000513102,0.00003601662,0.000001451071,0.0004061945],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003178781,"threshold_uncertainty_score":0.01063406,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1113204989995182,"score_gpt":0.3959878600491566,"score_spread":0.2846673610496384,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}