{"id":"W2924618784","doi":"10.2147/cmar.s189627","title":"&lt;p&gt;A systematic review of international guidelines and recommendations for the genetic screening, diagnosis, genetic counseling, and treatment of &lt;em&gt;BRCA&lt;/em&gt;-mutated breast cancer&lt;/p&gt;","year":2019,"lang":"en","type":"review","venue":"Cancer Management and Research","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":112,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"European Society for Medical Oncology; Pfizer","keywords":"Medicine; Guideline; Genetic counseling; BRCA mutation; Genetic testing; Breast cancer; Family medicine; MEDLINE; Cancer; Gynecology; Oncology; Internal medicine; Pathology; Genetics","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.001223303,0.0005226663,0.001372916,0.0003495594,0.0002598353,0.0001219594,0.0006365874,0.0002356278,0.0001309406],"category_scores_gemma":[0.0001359164,0.0003685359,0.0002960023,0.0004446682,0.0003198942,0.0000144694,0.000423264,0.0001384186,0.000002314626],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002836539,"about_ca_system_score_gemma":0.0004563415,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005995305,"about_ca_topic_score_gemma":0.0003627941,"domain_scores_codex":[0.9961642,0.0003811886,0.001395528,0.0009276858,0.0006676638,0.0004637254],"domain_scores_gemma":[0.9966639,0.0002993535,0.0007731161,0.0008403418,0.001298581,0.0001247586],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000482287,0.00009770208,0.00007726884,0.2938991,0.003299527,0.000003244671,0.000134579,0.00006324566,0.00007024658,0.00008040654,0.03914922,0.6630772],"study_design_scores_gemma":[0.0008845941,0.0002446489,0.0001407313,0.09954904,0.003047987,0.00002774052,0.00009944045,0.000443985,0.00003767823,0.0000163744,0.8951385,0.0003692563],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002795092,0.9901061,0.0004737884,0.00126473,0.0004103952,0.005949006,0.00143327,0.000009581962,0.00007364062],"genre_scores_gemma":[0.0001893214,0.9869057,0.001552892,0.0001209767,0.0004030569,0.007523449,0.0005493464,0.00008672428,0.00266853],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8559893,"threshold_uncertainty_score":0.9998767,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09430461330640981,"score_gpt":0.4147456970056947,"score_spread":0.3204410836992849,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}