{"id":"W2924618784","doi":"10.2147/cmar.s189627","title":"&lt;p&gt;A systematic review of international guidelines and recommendations for the genetic screening, diagnosis, genetic counseling, and treatment of &lt;em&gt;BRCA&lt;/em&gt;-mutated breast cancer&lt;/p&gt;","year":2019,"lang":"en","type":"review","venue":"Cancer Management and Research","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":112,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"European Society for Medical Oncology; Pfizer","keywords":"Medicine; Guideline; Genetic counseling; BRCA mutation; Genetic testing; Breast cancer; Family medicine; MEDLINE; Cancer; Gynecology; Oncology; Internal medicine; Pathology; Genetics","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01496553,0.001815772,0.007082033,0.01571438,0.001071464,0.002697348,0.003003804,0.002388144,0.005608616],"category_scores_gemma":[0.06786388,0.00133255,0.006624172,0.01618375,0.001251618,0.003190731,0.001947752,0.001609988,0.00062032],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.006208975,"about_ca_system_score_gemma":0.0313371,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01816753,"about_ca_topic_score_gemma":0.06067044,"domain_scores_codex":[0.9834774,0.005586844,0.007116439,0.0009601413,0.002418659,0.0004404828],"domain_scores_gemma":[0.958988,0.02369682,0.01030814,0.0006118303,0.005781909,0.0006133937],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"systematic_review","study_design_gemma":"systematic_review","study_design_scores_codex":[0.0001021689,0.0000114537,0.0007096904,0.9600752,0.003383092,0.00006769197,0.0003203844,0.0000770243,0.0001199083,0.0002848235,0.00533789,0.02951072],"study_design_scores_gemma":[0.0001589728,0.00006466511,0.001931266,0.9541577,0.02141277,0.0001347811,0.0002738016,0.00004615809,0.00009693765,0.000236878,0.02146108,0.00002501968],"study_design_candidate":"systematic_review","study_design_consensus":"systematic_review","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001246975,0.9916643,0.0004377059,0.001588779,0.0003001545,0.001405156,0.002364789,0.00002783264,0.0009643835],"genre_scores_gemma":[0.01172024,0.9793601,0.002349289,0.002084682,0.0001097734,0.002782299,0.001268574,0.00001845558,0.0003067254],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.01816753,"threshold_uncertainty_score":0.07914621,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09430461330640981,"score_gpt":0.4147456970056947,"score_spread":0.3204410836992849,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}