{"id":"W2924765283","doi":"10.2174/1573406415666190319101329","title":"Novel Amide Derivatives as Potent Tyrosinase Inhibitors; In-vitro, In-vivo Antimelanogenic Activity and Computational Studies","year":2019,"lang":"en","type":"article","venue":"Medicinal Chemistry","topic":"melanin and skin pigmentation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Laurentian University","funders":"National Research Foundation of Korea","keywords":"Tyrosinase; Kojic acid; Melanin; Chemistry; In vivo; Biochemistry; Arbutin; In vitro; Docking (animal); IC50; Enzyme; Stereochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001576998,0.0001422257,0.0001854801,0.00003036549,0.0000277867,0.00000885102,0.0000655943,0.00009625105,0.0000232228],"category_scores_gemma":[0.00008853839,0.0001351155,0.00002971561,0.00007858609,0.0001035668,0.000006844994,0.00007602095,0.0001126548,0.000003012066],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000413032,"about_ca_system_score_gemma":0.00006180022,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003159589,"about_ca_topic_score_gemma":0.000006643256,"domain_scores_codex":[0.9991404,0.00002292052,0.0001807825,0.0003155801,0.000173056,0.0001671954],"domain_scores_gemma":[0.9996795,0.00003488578,0.00007406718,0.0001151399,0.00004135916,0.00005504475],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002007134,0.00008325295,0.01129981,0.0001061449,0.0000282566,0.00001237419,0.0001771651,0.00008145199,0.9872811,0.000003769333,0.00009748829,0.0006284953],"study_design_scores_gemma":[0.001479674,0.00007029626,0.01984872,0.00007820794,0.000007807051,0.00005937673,0.0006235779,0.0001696863,0.9773301,0.00006032226,0.0001298541,0.0001423912],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973682,0.00127526,0.00009587089,0.0001781992,0.00008300929,0.0001293357,0.000008419186,0.000005089918,0.0008565981],"genre_scores_gemma":[0.9988102,0.0001451961,0.0002999534,0.0001331839,0.0001093136,0.00001187637,0.00005793169,0.00001029914,0.0004220707],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009950988,"threshold_uncertainty_score":0.5509852,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01109787131742905,"score_gpt":0.2754495586456963,"score_spread":0.2643516873282672,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}