{"id":"W2924765283","doi":"10.2174/1573406415666190319101329","title":"Novel Amide Derivatives as Potent Tyrosinase Inhibitors; In-vitro, In-vivo Antimelanogenic Activity and Computational Studies","year":2019,"lang":"en","type":"article","venue":"Medicinal Chemistry","topic":"melanin and skin pigmentation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Laurentian University","funders":"National Research Foundation of Korea","keywords":"Tyrosinase; Kojic acid; Melanin; Chemistry; In vivo; Biochemistry; Arbutin; In vitro; Docking (animal); IC50; Enzyme; Stereochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002613405,0.00089112,0.001165268,0.0003940946,0.0002421028,0.0006628222,0.000576924,0.0005258371,0.003498776],"category_scores_gemma":[0.0003105839,0.0002431719,0.001047558,0.000438272,0.0001494028,0.000385545,0.0002847334,0.0005325602,0.0005507699],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003787332,"about_ca_system_score_gemma":0.000395578,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002473209,"about_ca_topic_score_gemma":0.003745075,"domain_scores_codex":[0.9999338,0.00001491128,0.000003642195,0.00001543213,0.0000180645,0.00001394961],"domain_scores_gemma":[0.9999175,0.00003240039,0.00002003425,0.000004560935,0.00001496082,0.00001052047],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00135802,0.0009871427,0.004100326,0.004126095,0.0006552608,0.001573825,0.00007577045,0.8242568,0.08526514,0.00578604,0.005477177,0.06633832],"study_design_scores_gemma":[0.0004291538,0.003105697,0.001816419,0.000135385,0.0006261364,0.0005018147,0.0001093611,0.9388667,0.03029302,0.00181068,0.02222918,0.00007641919],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8560564,0.05498433,0.05301101,0.0008593125,0.0002801819,0.0003421698,0.004825283,0.001091612,0.02854965],"genre_scores_gemma":[0.9392222,0.01378114,0.03835996,0.0002512861,0.00006289135,0.0002422127,0.002758332,0.00009381325,0.005228113],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003498776,"threshold_uncertainty_score":0.0117045,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01109787131742905,"score_gpt":0.2754495586456963,"score_spread":0.2643516873282672,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}