{"id":"W2924767304","doi":"10.1128/jvi.00293-19","title":"Antibody-Induced Internalization of HIV-1 Env Proteins Limits Surface Expression of the Closed Conformation of Env","year":2019,"lang":"en","type":"article","venue":"Journal of Virology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; McGill University; Centre Hospitalier de l’Université de Montréal","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; Government of Canada; National Institutes of Health; National Institute of General Medical Sciences; Canada Research Chairs","keywords":"Internalization; Antibody-dependent cell-mediated cytotoxicity; Antibody; Biology; Gp41; Glycoprotein; Virology; Immune system; Cell biology; Flow cytometry; Neutralizing antibody; Cytotoxicity; In vitro; Cell; Molecular biology; Epitope; Monoclonal antibody; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001839544,0.0002144966,0.0002577475,0.0001151552,0.0001805327,0.0003605926,0.0002814668,0.0003931275,0.0006785127],"category_scores_gemma":[0.0002137332,0.0001072423,0.0003027874,0.00006829719,0.000324512,0.0002422543,0.0002853324,0.0007158888,0.0001985136],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003900851,"about_ca_system_score_gemma":0.0002201747,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006870996,"about_ca_topic_score_gemma":0.0009246353,"domain_scores_codex":[0.9997583,0.00005411029,0.00001457213,0.00003413516,0.00005988394,0.00007905653],"domain_scores_gemma":[0.999904,0.00003045471,0.00001601382,0.00001864598,0.00001717049,0.00001369768],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000472464,0.00003721266,0.0001767426,0.00002402882,0.000004503159,0.00003337236,0.00001360947,0.00009814707,0.9981274,0.0002038289,0.00001963686,0.001214222],"study_design_scores_gemma":[0.00001358548,0.0003865903,0.003812689,0.000006152945,0.00001110479,0.0002726812,0.00001683602,0.001487559,0.9930164,0.00006631936,0.0009058712,0.000004197261],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9951634,0.001092997,0.002368523,0.00006413063,0.00001494526,0.00001768492,0.00003143538,0.00002242565,0.001224384],"genre_scores_gemma":[0.997893,0.0002915813,0.0008792237,0.00004224123,0.000004508302,0.000004449616,0.00006130165,0.000006194979,0.0008175041],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006870996,"threshold_uncertainty_score":0.002830267,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0128425087279671,"score_gpt":0.2732101426170497,"score_spread":0.2603676338890826,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}