{"id":"W2924768710","doi":"10.1097/hs9.0000000000000233","title":"AXL Inhibition Extinguishes Primitive JAK2 Mutated Myeloproliferative Neoplasm Progenitor Cells","year":2019,"lang":"en","type":"article","venue":"HemaSphere","topic":"Myeloproliferative Neoplasms: Diagnosis and Treatment","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"Blood Cancer UK; Medical Research Council; Bloodwise; Cancer Research UK","keywords":"Myeloproliferative neoplasm; Essential thrombocythemia; Polycythemia vera; Myeloid leukemia; Cancer research; Thrombopoietin receptor; Janus kinase 2; Myeloproliferative Disorders; Myelofibrosis; Tyrosine kinase; Stem cell; Haematopoiesis; Myeloid; Medicine; Polycythaemia; Biology; Immunology; Internal medicine; Receptor; Bone marrow; Thrombopoietin; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0001535938,0.0004830058,0.0007053919,0.00007982283,0.0001617744,0.0000734248,0.00006862907,0.0002352353,0.002859322],"category_scores_gemma":[0.0001094539,0.0003879749,0.0002245085,0.0003288914,0.00008973829,0.0001878704,0.00006785007,0.0003484827,0.002473193],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002699863,"about_ca_system_score_gemma":0.0003065591,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003809988,"about_ca_topic_score_gemma":0.00003891532,"domain_scores_codex":[0.9975398,0.0001159127,0.0004996391,0.0007655511,0.0005239366,0.0005551742],"domain_scores_gemma":[0.9983717,0.0002055468,0.000214274,0.0004203669,0.000484015,0.0003040936],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003317045,0.007183152,0.5788128,0.002025642,0.003024537,0.003002899,0.01595476,0.000161229,0.3210686,0.006892093,0.0269144,0.03164286],"study_design_scores_gemma":[0.00641612,0.001560698,0.03548733,0.0007089083,0.0002621984,0.0002480288,0.001631451,0.0003043574,0.9419948,0.0001866689,0.01060672,0.0005926678],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9526554,0.0003345413,0.00003644552,0.0007150294,0.0004217694,0.002757211,0.00004387188,0.0002208653,0.04281488],"genre_scores_gemma":[0.9875635,0.00007925848,0.003325955,0.000791339,0.0003976319,0.0004662508,0.0001808715,0.00008283112,0.007112353],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6209263,"threshold_uncertainty_score":0.9998572,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007214455750966063,"score_gpt":0.2344571461380814,"score_spread":0.2272426903871153,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}