{"id":"W2924788224","doi":"10.1016/j.omtn.2019.03.003","title":"Characterization of HIV-1 Nucleoside-Modified mRNA Vaccines in Rabbits and Rhesus Macaques","year":2019,"lang":"en","type":"article","venue":"Molecular Therapy — Nucleic Acids","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":106,"is_retracted":false,"has_abstract":true,"ca_institutions":"Acuitas Therapeutics (Canada)","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; Bill and Melinda Gates Foundation","keywords":"Virology; Neutralization; Antibody; Vaccination; Virus; Biology; Nucleoside; Titer; Immune system; Immunology; Neutralizing antibody; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002816732,0.0002156165,0.0001677524,0.0002114478,0.0001302418,0.0002188818,0.0001633943,0.0002344778,0.0006352339],"category_scores_gemma":[0.0004328503,0.0001067929,0.0001862331,0.00009222569,0.0001857964,0.0001296922,0.0001126667,0.0002263523,0.0004230826],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002090283,"about_ca_system_score_gemma":0.0001423148,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001148389,"about_ca_topic_score_gemma":0.0009122704,"domain_scores_codex":[0.9998498,0.00003259325,0.00001443181,0.00003369253,0.00004392306,0.00002551749],"domain_scores_gemma":[0.9998615,0.00003421809,0.00003341714,0.00002210487,0.00003390378,0.00001497012],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005993201,0.00002726463,0.0003920145,0.00001745232,0.000003255696,0.00004915812,0.00003914924,0.00005093524,0.9974692,0.00007337487,0.00001516771,0.00180316],"study_design_scores_gemma":[0.0000318842,0.003070195,0.01164488,0.00001537872,0.00004295131,0.000736192,0.0000857307,0.001056883,0.9777273,0.000183847,0.005394846,0.000009790543],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918066,0.00115878,0.004349579,0.00006643533,0.00001683153,0.0001570722,0.0001927291,0.00003137985,0.00222066],"genre_scores_gemma":[0.9868621,0.001591987,0.005317837,0.0001114633,0.00001772934,0.000215571,0.0007181172,0.0000266062,0.005138681],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001148389,"threshold_uncertainty_score":0.002283454,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00891346113893823,"score_gpt":0.2389225854248842,"score_spread":0.2300091242859459,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}