{"id":"W2924812697","doi":"10.1158/2326-6066.cir-18-0499","title":"Multiple Immune-Suppressive Mechanisms in Fibrolamellar Carcinoma","year":2019,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver Foundation","funders":"National Cancer Institute","keywords":"Immune system; Tumor microenvironment; Cytotoxic T cell; Tumor-infiltrating lymphocytes; Immunohistochemistry; CD8; Cancer research; Immune checkpoint; PD-L1; Immunotherapy; Cancer; T cell; Medicine; Immunology; Biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002336339,0.0001967578,0.0001550251,0.0009025537,0.0002247305,0.0002710952,0.0001516245,0.0002590737,0.0006858089],"category_scores_gemma":[0.0003392086,0.00007141615,0.0001361069,0.000310122,0.0002589849,0.0002493994,0.0002597784,0.0001497356,0.000131537],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002475971,"about_ca_system_score_gemma":0.0001032089,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004690275,"about_ca_topic_score_gemma":0.0004809058,"domain_scores_codex":[0.9998916,0.0000216908,0.00001213351,0.00001787958,0.00003033219,0.00002630044],"domain_scores_gemma":[0.9998411,0.00003329468,0.00006332966,0.0000129757,0.00001943092,0.00002984377],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001196223,0.0001946482,0.6412565,0.0004687131,0.00008099533,0.02302075,0.0004699886,0.000498414,0.2632465,0.0009645876,0.0004715685,0.06813112],"study_design_scores_gemma":[0.00008767831,0.0007895579,0.8369101,0.0001084443,0.0001547783,0.09081244,0.0008423196,0.00377106,0.05767884,0.0008697765,0.007949102,0.00002590805],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933473,0.005186708,0.0004328731,0.00004067977,0.000005394375,0.00001327614,0.00003246056,0.00001988294,0.000921423],"genre_scores_gemma":[0.9994771,0.0002952275,0.0001032074,0.00001509051,0.000008664641,0.000003845784,0.00002268635,8.041222e-7,0.00007332427],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009025537,"threshold_uncertainty_score":0.002294242,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04080264750887871,"score_gpt":0.3513859023840613,"score_spread":0.3105832548751826,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}