{"id":"W2924812697","doi":"10.1158/2326-6066.cir-18-0499","title":"Multiple Immune-Suppressive Mechanisms in Fibrolamellar Carcinoma","year":2019,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver Foundation","funders":"National Cancer Institute","keywords":"Immune system; Tumor microenvironment; Cytotoxic T cell; Tumor-infiltrating lymphocytes; Immunohistochemistry; CD8; Cancer research; Immune checkpoint; PD-L1; Immunotherapy; Cancer; T cell; Medicine; Immunology; Biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0009307881,0.0002194661,0.0005320659,0.000579908,0.0001213749,0.00002749546,0.0004061779,0.0003668402,0.00299538],"category_scores_gemma":[0.0001189083,0.0001963038,0.0001635103,0.0008407346,0.000385592,0.0001186448,0.0002237989,0.00115615,0.0004228078],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006430953,"about_ca_system_score_gemma":0.0006754337,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002786396,"about_ca_topic_score_gemma":0.0001572221,"domain_scores_codex":[0.9972337,0.0003159937,0.0004282623,0.0005826253,0.0004715865,0.0009678716],"domain_scores_gemma":[0.9983791,0.0003121191,0.0000778511,0.0008583532,0.0002885081,0.00008410303],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.007190585,0.0001396885,0.1017966,0.000115416,0.0002231119,0.0001035456,0.0007353793,0.000006202667,0.8800414,0.0002600392,0.0005915907,0.008796537],"study_design_scores_gemma":[0.01449244,0.001678155,0.5250574,0.0004735119,0.00002440563,0.0001190177,0.002274679,0.0004323702,0.4322335,0.0005662378,0.02225999,0.0003882263],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9678093,0.02519818,0.0000137587,0.001855463,0.0006655731,0.001269063,0.00001978606,0.00004721658,0.003121705],"genre_scores_gemma":[0.9912325,0.001903493,0.0001309384,0.0002294903,0.00007732397,0.0003318649,0.00003046087,0.00005118728,0.00601279],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4478078,"threshold_uncertainty_score":0.997916,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04080264750887871,"score_gpt":0.3513859023840613,"score_spread":0.3105832548751826,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}