{"id":"W2924912121","doi":"10.1038/s41598-019-41533-2","title":"An Optogenetic Kindling Model of Neocortical Epilepsy","year":2019,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Photoreceptor and optogenetics research","field":"Neuroscience","cited_by":82,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre; Montreal General Hospital","funders":"National Institute on Aging; CIHR Skin Research Training Centre; Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; McGill University Health Centre; Canadian Institutes of Health Research; Savoy Foundation; Government of Canada; McGill University","keywords":"Epileptogenesis; Optogenetics; Neuroscience; Epilepsy; Kindling; Kindling model; Stimulation; Neuroplasticity; Psychology; Medicine; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000166897,0.0009771163,0.0003960134,0.0008308478,0.000250007,0.0002325435,0.0004697895,0.0006500038,0.001536766],"category_scores_gemma":[0.0001273586,0.0002214884,0.0004483019,0.000326163,0.0006369502,0.0004506958,0.0004181747,0.0013653,0.0003444947],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000396243,"about_ca_system_score_gemma":0.0004734595,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005867908,"about_ca_topic_score_gemma":0.001158508,"domain_scores_codex":[0.9997603,0.00002136903,0.00002974376,0.00005868941,0.00007913431,0.00005066229],"domain_scores_gemma":[0.9997831,0.00003159755,0.000070175,0.00003578795,0.00001132554,0.00006803254],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001772498,0.0001257941,0.00009791688,0.00004202894,0.000006487987,0.0002082294,0.00002695913,0.0001777754,0.9968268,0.0005877786,0.00009294734,0.001629849],"study_design_scores_gemma":[0.00009429036,0.001719135,0.002798015,0.00001722377,0.00003496341,0.001148754,0.00003760171,0.002640206,0.9870171,0.0006242816,0.003845855,0.00002267417],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9715874,0.0007280285,0.02103096,0.0006422335,0.0002892009,0.0004529183,0.001493826,0.0007331418,0.003042272],"genre_scores_gemma":[0.9675298,0.001149141,0.02070314,0.0002498102,0.00004241134,0.0006459384,0.0008489855,0.0001001435,0.008730534],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001536766,"threshold_uncertainty_score":0.00514096,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05164456544045752,"score_gpt":0.3295596442826472,"score_spread":0.2779150788421896,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}