{"id":"W2924912121","doi":"10.1038/s41598-019-41533-2","title":"An Optogenetic Kindling Model of Neocortical Epilepsy","year":2019,"lang":"en","type":"article","venue":"Scientific Reports","topic":"Photoreceptor and optogenetics research","field":"Neuroscience","cited_by":82,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre; Montreal General Hospital","funders":"National Institute on Aging; CIHR Skin Research Training Centre; Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; McGill University Health Centre; Canadian Institutes of Health Research; Savoy Foundation; Government of Canada; McGill University","keywords":"Epileptogenesis; Optogenetics; Neuroscience; Epilepsy; Kindling; Kindling model; Stimulation; Neuroplasticity; Psychology; Medicine; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009662885,0.0001330533,0.000210748,0.0002238551,0.0001509431,0.000185779,0.0004187701,0.00007686493,0.0005060527],"category_scores_gemma":[0.0003094561,0.0001202068,0.000101495,0.0005531813,0.0003761291,0.0001839681,0.0001380137,0.0001548217,0.0001152941],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002955633,"about_ca_system_score_gemma":0.0002782685,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007245405,"about_ca_topic_score_gemma":0.000002516862,"domain_scores_codex":[0.9967584,0.00008926227,0.0005130062,0.001029344,0.001126192,0.0004837802],"domain_scores_gemma":[0.9979939,0.00006394822,0.0001653308,0.001373795,0.0001364539,0.00026659],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001315429,0.0001126587,0.01226869,0.00001712587,0.000001388157,0.00002729204,0.0001783147,0.01178153,0.9745837,0.0001970037,0.00009738732,0.0007217686],"study_design_scores_gemma":[0.00008309163,0.0000672645,0.0004302567,0.00001135888,0.000003875801,0.00003923108,0.00001897564,0.1357337,0.8588786,0.004231294,0.000378261,0.0001240877],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9916956,0.00001975076,0.0007099767,0.00001244564,0.002502119,0.000413064,0.000005207495,0.00004062658,0.004601229],"genre_scores_gemma":[0.9973551,0.000004841151,0.001090366,0.00002890364,0.00002983526,0.00001298268,0.000005781525,0.00002134755,0.001450817],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1239521,"threshold_uncertainty_score":0.5540922,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05164456544045752,"score_gpt":0.3295596442826472,"score_spread":0.2779150788421896,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}