{"id":"W2925092419","doi":"10.1056/nejmoa1811714","title":"Overall Survival with Fulvestrant plus Anastrozole in Metastatic Breast Cancer","year":2019,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":128,"is_retracted":false,"has_abstract":true,"ca_institutions":"London Health Sciences Centre; Cancer Care Ontario","funders":"National Cancer Institute","keywords":"Anastrozole; Fulvestrant; Medicine; Oncology; Aromatase inhibitor; Metastatic breast cancer; Internal medicine; Aromatase; Breast cancer; Cancer; Tamoxifen; Estrogen receptor; Progression-free survival; Overall survival","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0004838842,0.0002057322,0.0008411653,0.0002470005,0.00001468398,0.00000574361,0.0001157248,0.00003224788,0.001040114],"category_scores_gemma":[0.00002751608,0.000117731,0.00005480228,0.0002376438,0.00009742473,0.0001835199,0.00001066761,0.0004769971,0.000004907137],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002205867,"about_ca_system_score_gemma":0.0006379827,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006785398,"about_ca_topic_score_gemma":0.0003275482,"domain_scores_codex":[0.9983039,0.000066052,0.0005050509,0.0001610622,0.0006684496,0.0002954114],"domain_scores_gemma":[0.9988732,0.0001155677,0.0003176162,0.000183691,0.0001929308,0.0003169339],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.05306078,0.0003603701,0.4590597,0.0005278108,0.001334147,0.003289557,0.0057102,0.0109321,0.02710343,0.0004768454,0.000871982,0.4372731],"study_design_scores_gemma":[0.3511469,0.005106139,0.5920163,0.004897148,0.0005790354,0.01700284,0.00169212,0.0002958654,0.0003855464,0.0005443792,0.02598504,0.0003487192],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9786615,0.002269406,0.001169747,0.01654592,0.0005755243,0.0002423203,0.000009002059,0.00001136584,0.0005151956],"genre_scores_gemma":[0.9951838,0.0002801339,0.001305639,0.0007308581,0.001880021,0.000002043616,0.000003669989,0.00003085058,0.0005829679],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4369243,"threshold_uncertainty_score":0.999873,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01613558606668913,"score_gpt":0.2899758635197193,"score_spread":0.2738402774530302,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}