{"id":"W2925126737","doi":"10.1021/acsnano.8b07858","title":"Lipid-Based DNA Therapeutics: Hallmarks of Non-Viral Gene Delivery","year":2019,"lang":"en","type":"review","venue":"ACS Nano","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":309,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Freiwillige Akademische Gesellschaft; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Novartis","keywords":"Gene delivery; Genetic enhancement; Computational biology; DNA; Gene; Ex vivo; Biology; In vivo; Bioinformatics; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000159921,0.0004521389,0.001048395,0.0001256066,0.00003540179,0.00002278089,0.0006929268,0.0007217654,0.00003758689],"category_scores_gemma":[0.00001479855,0.0003761721,0.000715905,0.0001054519,0.00008536516,0.000003867483,0.0001788348,0.0001819453,0.0001674764],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002567249,"about_ca_system_score_gemma":0.0006213429,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000267358,"about_ca_topic_score_gemma":0.000009197927,"domain_scores_codex":[0.9982505,0.0001066992,0.0005800202,0.0005600196,0.0001757984,0.0003269648],"domain_scores_gemma":[0.9983932,0.00003346018,0.0003986058,0.0009582503,0.0001586479,0.00005786855],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007714819,0.0001533001,0.00002433481,0.004961298,0.0008605248,0.000007234213,0.00001654703,0.000009717175,0.1991858,0.000003979543,0.003905272,0.7907948],"study_design_scores_gemma":[0.0002957521,0.00051771,0.000004211566,0.001455758,0.0005637628,0.000009649558,0.000003297063,0.000005885393,0.07523464,0.000002566799,0.9214742,0.0004325923],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.01338263,0.9845757,0.0001206001,0.000008358209,0.0005250048,0.0004517319,0.000147719,0.000008522604,0.0007796648],"genre_scores_gemma":[0.006823974,0.9895518,0.0001731566,0.0003279302,0.0003503522,0.00004183457,0.0009749061,0.00007207696,0.001684014],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9175689,"threshold_uncertainty_score":0.999869,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03361394364920768,"score_gpt":0.3033772125000103,"score_spread":0.2697632688508026,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}