{"id":"W2925126737","doi":"10.1021/acsnano.8b07858","title":"Lipid-Based DNA Therapeutics: Hallmarks of Non-Viral Gene Delivery","year":2019,"lang":"en","type":"review","venue":"ACS Nano","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":309,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Freiwillige Akademische Gesellschaft; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Novartis","keywords":"Gene delivery; Genetic enhancement; Computational biology; DNA; Gene; Ex vivo; Biology; In vivo; Bioinformatics; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004535291,0.000707307,0.0009727033,0.001819695,0.000271212,0.0008603152,0.000596803,0.00108809,0.001499411],"category_scores_gemma":[0.0003958759,0.0002839443,0.0003481527,0.001261504,0.0007590182,0.001042168,0.000694744,0.001862848,0.001726448],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007251926,"about_ca_system_score_gemma":0.0007189401,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005238698,"about_ca_topic_score_gemma":0.000732569,"domain_scores_codex":[0.99975,0.00004354885,0.00001975526,0.00004097146,0.0001237598,0.00002207595],"domain_scores_gemma":[0.9998552,0.00006872919,0.00002252889,0.000007133423,0.0000319029,0.0000144771],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006684219,0.0001381431,0.0001330392,0.0166409,0.00005898049,0.0004733908,0.0001927916,0.0008033154,0.06151878,0.03467206,0.01365813,0.8716437],"study_design_scores_gemma":[0.00000951421,0.0001383268,0.000250642,0.001097174,0.00003417864,0.001429635,0.00004626892,0.0001596411,0.0189006,0.003499485,0.9744095,0.00002493138],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0006634582,0.9914409,0.002517432,0.0003817414,0.0003079692,0.00002017976,0.00003357884,0.00003506624,0.00459967],"genre_scores_gemma":[0.003742866,0.9911885,0.001992415,0.0002692698,0.0001756964,0.00003562215,0.0000462535,0.000008242539,0.002541133],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001819695,"threshold_uncertainty_score":0.00526166,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03361394364920768,"score_gpt":0.3033772125000103,"score_spread":0.2697632688508026,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}