{"id":"W2925139051","doi":"10.1016/j.jtho.2019.03.007","title":"Updated Efficacy and Safety Data and Impact of the EML4-ALK Fusion Variant on the Efficacy of Alectinib in Untreated ALK-Positive Advanced Non–Small Cell Lung Cancer in the Global Phase III ALEX Study","year":2019,"lang":"en","type":"article","venue":"Journal of Thoracic Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":491,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Sunnybrook Health Science Centre","funders":"Merck Sharp and Dohme; Genentech; F. Hoffmann-La Roche; Amgen; Ariad Pharmaceuticals; Roche; Novartis; Celgene; Bristol-Myers Squibb; AstraZeneca; Pfizer; AbbVie; Merck","keywords":"Alectinib; Medicine; Lung cancer; Crizotinib; Oncology; Internal medicine; Cancer research","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.007501107,0.0009114631,0.001700021,0.0003653186,0.0001805525,0.001222503,0.000734945,0.0004877313,0.00154758],"category_scores_gemma":[0.003587858,0.0002678644,0.002861666,0.0006999576,0.0007047034,0.000702725,0.0005882403,0.00129399,0.0003053268],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000706878,"about_ca_system_score_gemma":0.0009269101,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006505412,"about_ca_topic_score_gemma":0.002289759,"domain_scores_codex":[0.9978673,0.001242706,0.0001247261,0.0002378494,0.0003861384,0.0001411048],"domain_scores_gemma":[0.9966471,0.001071871,0.00136733,0.0003942522,0.0002640089,0.0002554735],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.625515,0.00223409,0.1596321,0.002770374,0.03154852,0.0004203648,0.0003932529,0.009940762,0.0174168,0.0007343457,0.0107769,0.1386174],"study_design_scores_gemma":[0.191763,0.09718373,0.6363362,0.0004097001,0.0385906,0.001318068,0.0002270315,0.004129115,0.007458234,0.001525886,0.02086793,0.0001904487],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9833089,0.007621725,0.0006028656,0.0005005196,0.00006953697,0.0002690251,0.00473138,0.00006112231,0.002835018],"genre_scores_gemma":[0.986105,0.002202736,0.000580917,0.0006059156,0.0001211382,0.0001981968,0.009409739,0.00003231135,0.0007440128],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007501107,"threshold_uncertainty_score":0.03967011,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01789835229157475,"score_gpt":0.4489390676521736,"score_spread":0.4310407153605988,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}