{"id":"W2925329803","doi":"10.3390/challe10010023","title":"Multiomics and Systems Biology Are Needed to Unravel the Complex Origins of Chronic Disease","year":2019,"lang":"en","type":"article","venue":"Challenges","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Disease; Systems biology; Omics; Immune dysregulation; Data science; Domain (mathematical analysis); Immune system; Chronic disease; Biology; Computational biology; Cognitive science; Medicine; Psychology; Computer science; Bioinformatics; Immunology; Intensive care medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.01366576,0.001400631,0.003979141,0.003341592,0.002039661,0.007895428,0.002164372,0.005003573,0.005102357],"category_scores_gemma":[0.007577593,0.0007779837,0.002056136,0.002254985,0.0102002,0.01642204,0.009209144,0.0139583,0.001147386],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003371198,"about_ca_system_score_gemma":0.008332937,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003236093,"about_ca_topic_score_gemma":0.004429339,"domain_scores_codex":[0.9964951,0.001747569,0.0002254971,0.000583942,0.0006022824,0.0003456363],"domain_scores_gemma":[0.983567,0.01033688,0.001032838,0.002005737,0.001386263,0.001671272],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"theoretical_or_conceptual","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0002998689,0.0004145811,0.02435685,0.00655196,0.002022214,0.0009253611,0.003991358,0.008236548,0.02730853,0.6064268,0.02855043,0.2909155],"study_design_scores_gemma":[0.00002790145,0.0002597968,0.01244457,0.001405474,0.0002113844,0.0005058651,0.004194017,0.003646457,0.001344903,0.8269017,0.1488514,0.0002065676],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":"theoretical_or_conceptual","genre_codex":"review","genre_gemma":"commentary","genre_scores_codex":[0.02979264,0.3792665,0.236484,0.3272071,0.006922495,0.0003428468,0.001301922,0.0007549637,0.01792772],"genre_scores_gemma":[0.201622,0.3861361,0.339668,0.05273351,0.01162514,0.001050548,0.001031849,0.0003109075,0.005821857],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.01366576,"threshold_uncertainty_score":0.07227236,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02628231937383068,"score_gpt":0.2644244021833038,"score_spread":0.2381420828094731,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}