{"id":"W2925329803","doi":"10.3390/challe10010023","title":"Multiomics and Systems Biology Are Needed to Unravel the Complex Origins of Chronic Disease","year":2019,"lang":"en","type":"article","venue":"Challenges","topic":"Diabetes and associated disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Disease; Systems biology; Omics; Immune dysregulation; Data science; Domain (mathematical analysis); Immune system; Chronic disease; Biology; Computational biology; Cognitive science; Medicine; Psychology; Computer science; Bioinformatics; Immunology; Intensive care medicine; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007432251,0.00009069465,0.0001333957,0.00001923035,0.00002950574,0.000008488077,0.0001232471,0.00006876384,0.000004628341],"category_scores_gemma":[0.00002694962,0.00006588255,0.00003740649,0.00002896451,0.0000519864,0.000001211459,0.00008026453,0.0000337315,0.000008285774],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000168912,"about_ca_system_score_gemma":0.00002832473,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005991601,"about_ca_topic_score_gemma":0.00006059523,"domain_scores_codex":[0.9994784,0.00003607137,0.00009826857,0.0001912215,0.00003947795,0.0001565613],"domain_scores_gemma":[0.9995809,0.00001832201,0.00006761112,0.0002264762,0.0000433027,0.00006341754],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002252427,0.0005036311,0.02807016,0.001052997,0.0007202519,0.000001956767,0.001061553,0.001697489,0.9067411,0.03412917,0.005193095,0.02060332],"study_design_scores_gemma":[0.004295473,0.001693793,0.1052674,0.0002638602,0.0001344183,0.000002671717,0.02025517,0.005060348,0.01420862,0.0004521033,0.8473212,0.001044947],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9788962,0.01817512,0.00002151656,0.002122857,0.0001498243,0.0002415552,0.00007092991,0.00000599021,0.0003160028],"genre_scores_gemma":[0.9963285,0.003215444,0.000008537454,0.000202038,0.00008122524,0.000014915,0.00004402124,0.00001095652,0.00009435192],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8925325,"threshold_uncertainty_score":0.2686613,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02628231937383068,"score_gpt":0.2644244021833038,"score_spread":0.2381420828094731,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}