{"id":"W2925338610","doi":"10.1016/j.bbrc.2019.03.068","title":"Peptides with the multibasic cleavage site of the hemagglutinin from highly pathogenic influenza viruses act as cell-penetrating via binding to heparan sulfate and neuropilins","year":2019,"lang":"en","type":"article","venue":"Biochemical and Biophysical Research Communications","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Japan Society for the Promotion of Science; Public Health Agency of Canada","keywords":"Internalization; Heparan sulfate; Hemagglutinin (influenza); Chemistry; Influenza A virus; Antigen; Cleavage (geology); Virus; Cell; Virology; Biology; Biochemistry; Immunology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001988344,0.0003788379,0.0001926559,0.0001082218,0.0001584485,0.0002289516,0.0002170565,0.000352096,0.00101378],"category_scores_gemma":[0.0001209123,0.0001469875,0.0002836388,0.00008144201,0.0001953259,0.0002173124,0.0002154986,0.0004128855,0.0004276115],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001537795,"about_ca_system_score_gemma":0.0001152719,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001819281,"about_ca_topic_score_gemma":0.0002713167,"domain_scores_codex":[0.999859,0.0000348375,0.000008269511,0.00001995555,0.00004264176,0.00003526843],"domain_scores_gemma":[0.9999174,0.00001747091,0.00002066364,0.000007180513,0.00001006589,0.00002737772],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007548306,0.000009415243,0.00009667394,0.00002023986,0.000004698089,0.00005898079,0.00001041541,0.00006775394,0.9983312,0.0002173403,0.00003372349,0.001074157],"study_design_scores_gemma":[0.00001741034,0.0002092068,0.001853357,0.000003149333,0.000008865698,0.0004491761,0.00001249435,0.0004963956,0.9952164,0.00008796885,0.001641497,0.000004027278],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907488,0.0008126443,0.006047108,0.00007579096,0.00003743819,0.00005024332,0.0001161538,0.00003833777,0.002073456],"genre_scores_gemma":[0.9902666,0.0004393889,0.006439404,0.0001395445,0.00001554702,0.00002102051,0.0002827805,0.00001632873,0.002379332],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00101378,"threshold_uncertainty_score":0.003391445,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03959430391038508,"score_gpt":0.3266414209799269,"score_spread":0.2870471170695418,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}