{"id":"W2925455345","doi":"10.1016/j.jalz.2019.01.015","title":"Longitudinal cerebrospinal fluid biomarker trajectories along the Alzheimer's disease continuum in the BIOMARKAPD study","year":2019,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":127,"is_retracted":false,"has_abstract":true,"ca_institutions":"Douglas Mental Health University Institute","funders":"H2020 European Research Council; Fonds de Recherche du Québec - Santé; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas; Ministero della Salute; Vetenskapsrådet; Eusko Jaurlaritza; Instituto de Salud Carlos III; ZonMw; Royal Swedish Academy of Sciences; Sixth Framework Programme; Fujirebio Europe; Innovationsfonden; European Regional Development Fund; European Commission; EU Joint Programme – Neurodegenerative Disease Research; Bundesministerium für Bildung und Forschung; Biogen","keywords":"Cerebrospinal fluid; Biomarker; Tau protein; Internal medicine; Medicine; Dementia; Alzheimer's disease; Oncology; Gastroenterology; Psychology; Disease; Pathology; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001304982,0.000503107,0.0007032017,0.0008169287,0.0008900054,0.001253851,0.0004938478,0.000700633,0.0006097302],"category_scores_gemma":[0.003074635,0.0004285672,0.0005027527,0.001272418,0.0003371403,0.0008481863,0.001143023,0.0006771449,0.0002141639],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005268383,"about_ca_system_score_gemma":0.0005107078,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.009716291,"about_ca_topic_score_gemma":0.01042603,"domain_scores_codex":[0.9993379,0.0001779559,0.00008325122,0.0001946757,0.0001166345,0.00008963653],"domain_scores_gemma":[0.998692,0.0001485387,0.0005308482,0.0001603392,0.0002492605,0.0002189732],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003734314,0.00003393188,0.9978541,0.00001077422,0.00009834579,0.0001006384,0.000136129,0.0000348911,0.0001820968,0.00001870299,0.000139438,0.00101765],"study_design_scores_gemma":[0.00002677037,0.0001390054,0.9987778,0.00001014844,0.00005934946,0.0002334587,0.000145002,0.00009917926,0.00007559544,0.00007216367,0.000354184,0.000007355256],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981532,0.0003091575,0.00009589819,0.00005141634,0.000007415178,0.00001024823,0.001145143,0.000005187659,0.0002223735],"genre_scores_gemma":[0.9978784,0.0001268013,0.0001765415,0.00003743114,0.000009393909,0.00002802666,0.001568418,0.000002723507,0.0001722378],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009716291,"threshold_uncertainty_score":0.01931947,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03867641389381477,"score_gpt":0.3218647036263043,"score_spread":0.2831882897324896,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}