{"id":"W2925809108","doi":"10.3389/fendo.2019.00206","title":"ERRα as a Bridge Between Transcription and Function: Role in Liver Metabolism and Disease","year":2019,"lang":"en","type":"review","venue":"Frontiers in Endocrinology","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":100,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Canadian Institutes of Health Research","keywords":"AMPK; Cell biology; Transcription factor; Nuclear receptor; Biology; Effector; Transcriptional regulation; PI3K/AKT/mTOR pathway; Regulation of gene expression; Function (biology); Energy homeostasis; Kinase; Cell metabolism; Receptor; Signal transduction; Protein kinase A; Gene; Metabolism; Genetics; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004787929,0.0004832764,0.0008343725,0.0005377652,0.0002065965,0.0008730403,0.0004972322,0.0007446372,0.001773587],"category_scores_gemma":[0.0003557025,0.0001415761,0.0003116166,0.0007096268,0.0004818419,0.0006893914,0.0005702415,0.001144809,0.001132717],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003418193,"about_ca_system_score_gemma":0.0004862461,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004180599,"about_ca_topic_score_gemma":0.0006157573,"domain_scores_codex":[0.9997932,0.00005042126,0.00002934829,0.00005244766,0.00004727555,0.00002732219],"domain_scores_gemma":[0.9998423,0.00005156695,0.00003474372,0.000007191739,0.00004211811,0.00002218444],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007873912,0.00008724112,0.002539317,0.01641733,0.0002608598,0.001640751,0.0005223611,0.001263872,0.07691121,0.04059619,0.03119144,0.827782],"study_design_scores_gemma":[0.00002742214,0.0002904148,0.005973398,0.001423219,0.0001953021,0.004005161,0.0002629882,0.0003419222,0.01112745,0.009298749,0.9670019,0.00005222043],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002288332,0.992935,0.001295681,0.0009672413,0.000456426,0.000003978358,0.00007805743,0.00002747188,0.001947739],"genre_scores_gemma":[0.01970997,0.9741829,0.001114393,0.0007923982,0.001038438,0.00001243645,0.0002116094,0.00001069444,0.002927268],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001773587,"threshold_uncertainty_score":0.005933285,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01580535973912392,"score_gpt":0.2625550132190742,"score_spread":0.2467496534799502,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}