{"id":"W2926044788","doi":"10.1021/acs.biochem.9b00066","title":"Unveiling the Distinct Mechanisms by which Disease-Causing Mutations in the Kelch Domain of KLHL3 Disrupt the Interaction with the Acidic Motif of WNK4 through Molecular Dynamics Simulation","year":2019,"lang":"en","type":"article","venue":"Biochemistry","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Natural Sciences and Engineering Research Council of Canada","keywords":"Mutation; Biology; Ubiquitin; Cell biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003598972,0.0007817028,0.0008951908,0.0004482891,0.0009597816,0.0005825415,0.001009374,0.001014956,0.001727224],"category_scores_gemma":[0.0009831687,0.0004138073,0.0007772468,0.0003557466,0.0006981163,0.0005375466,0.0005043785,0.0009407373,0.0001383265],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001111808,"about_ca_system_score_gemma":0.001616381,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.01942085,"about_ca_topic_score_gemma":0.01307817,"domain_scores_codex":[0.9998878,0.00002555445,0.000005018416,0.00001309535,0.00002405472,0.00004437034],"domain_scores_gemma":[0.9995752,0.0002071225,0.0000438852,0.00002882347,0.00007309951,0.00007192435],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0002135666,0.0002508945,0.004998562,0.0000738048,0.0001188602,0.0001510639,0.0001019601,0.98152,0.00628835,0.003906104,0.0004807838,0.001895979],"study_design_scores_gemma":[0.00004442068,0.0000365829,0.0006334104,0.000005326942,0.0000137508,0.000005184833,0.0000278269,0.9981195,0.000503389,0.0003877007,0.0002168659,0.000005976603],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9887342,0.0001864149,0.00538946,0.0002779189,0.0000493905,0.00005583967,0.0002521377,0.0001330146,0.004921662],"genre_scores_gemma":[0.9938434,0.0001463729,0.004865564,0.00008330586,0.00001296752,0.0001270999,0.0003308413,0.00004273207,0.0005476934],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01942085,"threshold_uncertainty_score":0.03861558,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008033810855936097,"score_gpt":0.2775259942778929,"score_spread":0.2694921834219568,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}