{"id":"W2926334753","doi":"10.1016/j.celrep.2019.03.019","title":"Global Characterization of X Chromosome Inactivation in Human Pluripotent Stem Cells","year":2019,"lang":"en","type":"article","venue":"Cell Reports","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":70,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Azrieli Foundation; Israel Science Foundation; United States-Israel Binational Science Foundation","keywords":"XIST; X-inactivation; Biology; Induced pluripotent stem cell; Epigenetics; Dosage compensation; Embryonic stem cell; X chromosome; Genetics; Long non-coding RNA; Gene silencing; Cell biology; Gene; RNA","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007002194,0.00007102925,0.00009276413,0.00002354412,0.000008252864,0.000004838254,0.00003604409,0.00007212751,0.00001416772],"category_scores_gemma":[0.000001799648,0.00007647107,0.00003211409,0.00006879253,0.000007538856,0.000002734814,0.00003202695,0.00002386594,0.000001537533],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002189311,"about_ca_system_score_gemma":0.00002161386,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001207652,"about_ca_topic_score_gemma":0.000003615451,"domain_scores_codex":[0.9994066,0.000009027387,0.0002279701,0.0001853826,0.00007613913,0.00009486406],"domain_scores_gemma":[0.9996099,9.666938e-7,0.0001162743,0.000219779,0.00002977704,0.00002324966],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000004491288,0.00003368741,0.01880598,0.00004482292,0.000003511214,0.000007479101,0.0000177528,0.0008449258,0.9798805,0.000003916565,0.00001022657,0.0003426723],"study_design_scores_gemma":[0.0001277047,0.00006494002,0.05206918,0.0000141105,0.000002865617,0.00001104445,0.00001286824,0.0000465638,0.94608,0.000006197801,0.001488325,0.00007614643],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973682,0.00005415874,0.001151944,0.00000371327,0.0002088982,0.0001621171,0.000002969481,0.000004979473,0.001043048],"genre_scores_gemma":[0.9992261,0.00001826076,0.00003271582,0.000009158325,0.00003952804,0.000004521933,0.00008706906,0.000007966504,0.0005746584],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03380049,"threshold_uncertainty_score":0.31184,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004464958650481352,"score_gpt":0.2374176271261844,"score_spread":0.232952668475703,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}