{"id":"W2926378013","doi":"10.1016/j.omtm.2019.03.005","title":"PGE2 and Poloxamer Synperonic F108 Enhance Transduction of Human HSPCs with a β-Globin Lentiviral Vector","year":2019,"lang":"en","type":"article","venue":"Molecular Therapy — Methods & Clinical Development","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California Los Angeles; Health Sciences Centre Foundation; National Institute of General Medical Sciences; California Institute for Regenerative Medicine","keywords":"Transduction (biophysics); Genetic enhancement; Haematopoiesis; Progenitor cell; Viral vector; Biology; Transgene; Stem cell; Cancer research; Immunology; Cell biology; Gene; Genetics; Recombinant DNA","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002174526,0.0003645919,0.0002438994,0.0002412956,0.00006441315,0.0002620384,0.0001252428,0.000234304,0.0008135991],"category_scores_gemma":[0.00007358292,0.000100146,0.0001968542,0.0001338558,0.0001575068,0.0001374127,0.0001665082,0.000432616,0.0002904249],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001796828,"about_ca_system_score_gemma":0.0001571462,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002740564,"about_ca_topic_score_gemma":0.0003498451,"domain_scores_codex":[0.9998538,0.00002826453,0.00001539218,0.00003134983,0.00004768254,0.00002350225],"domain_scores_gemma":[0.999951,0.00001088855,0.0000148074,0.00000572788,0.00000471756,0.00001288246],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003533779,0.00003335428,0.00006368061,0.00001866413,0.000002876595,0.00001981142,0.000007885777,0.0000707676,0.9986109,0.00005002798,0.0000221604,0.001064645],"study_design_scores_gemma":[0.00001199313,0.0002609755,0.0005452405,0.00000195809,0.000007399968,0.00009816064,0.000003817745,0.0004248942,0.9974176,0.000008131903,0.00121853,0.000001297049],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9867062,0.001231678,0.009241186,0.00006989657,0.00003482364,0.0001522156,0.0003147766,0.0001383855,0.002110844],"genre_scores_gemma":[0.9842774,0.0007673337,0.01005098,0.00005669731,0.0000155445,0.00008193717,0.0005025025,0.00003484276,0.004212864],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008135991,"threshold_uncertainty_score":0.002721786,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0413253131754646,"score_gpt":0.4271386880818766,"score_spread":0.385813374906412,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}