{"id":"W2926463281","doi":"10.3389/fphar.2019.00332","title":"Venlafaxine Improves the Cognitive Impairment and Depression-Like Behaviors in a Cuprizone Mouse Model by Alleviating Demyelination and Neuroinflammation in the Brain","year":2019,"lang":"en","type":"article","venue":"Frontiers in Pharmacology","topic":"Neuroinflammation and Neurodegeneration Mechanisms","field":"Neuroscience","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; University of Alberta; University of Saskatchewan","funders":"National Natural Science Foundation of China; Saskatchewan Health Research Foundation; University of Saskatchewan","keywords":"Neuroinflammation; Venlafaxine; Myelin; Multiple sclerosis; Psychology; Neuroscience; Neuroprotection; Medicine; Antidepressant; Microglia; Cognitive decline; Mood; Inflammation; Internal medicine; Dementia; Immunology; Central nervous system; Psychiatry; Hippocampus; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006386131,0.0001602668,0.00016861,0.000221175,0.0001084371,0.00005133694,0.000175216,0.00006909842,0.000008719029],"category_scores_gemma":[0.0001862569,0.0001198801,0.00001899883,0.0002565008,0.00007593619,0.0003041206,0.00008864955,0.0003661953,0.000002495483],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004289053,"about_ca_system_score_gemma":0.00002861446,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008723161,"about_ca_topic_score_gemma":0.00001965214,"domain_scores_codex":[0.9979794,0.0007620775,0.0003697001,0.0004377128,0.0002029614,0.0002481538],"domain_scores_gemma":[0.9992681,0.0004079506,0.0001591918,0.0001072943,0.00001965403,0.0000378373],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0001294904,0.00008896748,0.003549704,0.00001369177,0.000001266029,0.00001018818,0.002207549,0.001498361,0.9884778,0.00006814115,0.001164809,0.002790038],"study_design_scores_gemma":[0.003312607,0.0001312937,0.004629473,0.00001428463,0.00001250913,0.0000160793,0.0005755255,0.5298561,0.460862,0.0003301025,0.00009436141,0.0001656274],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940958,0.00007171787,0.001450491,0.002478156,0.0004499708,0.001390882,0.00001115452,0.00002279058,0.0000290555],"genre_scores_gemma":[0.9953379,0.0002308207,0.0001772044,0.00386399,0.00002384997,0.0001897116,0.0000078122,0.00001720384,0.0001515253],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5283578,"threshold_uncertainty_score":0.488857,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01221377924800049,"score_gpt":0.2729661125268855,"score_spread":0.260752333278885,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}