{"id":"W2926623862","doi":"10.1063/1.5087122","title":"Challenges and opportunities in exosome research—Perspectives from biology, engineering, and cancer therapy","year":2019,"lang":"en","type":"review","venue":"APL Bioengineering","topic":"Extracellular vesicles in disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":562,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia, Okanagan Campus; University of British Columbia; BC Cancer Agency","funders":"Natural Sciences and Engineering Research Council of Canada; University of British Columbia","keywords":"Exosome; Microvesicles; Extracellular vesicles; Endosome; Biology; Computational biology; Biogenesis; Cell biology; microRNA; Intracellular; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002000374,0.0009458132,0.001643124,0.0025555,0.0004403598,0.002171076,0.001259761,0.002339746,0.002158642],"category_scores_gemma":[0.001265239,0.0003601886,0.0007065793,0.002567148,0.001669458,0.004803165,0.001534458,0.004205536,0.001642084],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001276555,"about_ca_system_score_gemma":0.001634322,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007806082,"about_ca_topic_score_gemma":0.001118603,"domain_scores_codex":[0.9995564,0.0001097385,0.00005757956,0.00006694696,0.000158783,0.00005048836],"domain_scores_gemma":[0.9991204,0.000517526,0.00005571499,0.00002960664,0.000186462,0.00009018796],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001064126,0.0001297692,0.0002084961,0.01857307,0.0000803673,0.0004047992,0.0001873213,0.0008172307,0.004838273,0.03266492,0.04071636,0.901273],"study_design_scores_gemma":[0.00001318425,0.0001194197,0.0004286183,0.003576519,0.00003749002,0.001049286,0.000157611,0.0002298562,0.0008844701,0.01185435,0.9816202,0.00002904692],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00005538745,0.9983168,0.000192437,0.0007871697,0.0002645994,0.000001587027,0.000004294376,0.000004448094,0.0003733353],"genre_scores_gemma":[0.0003733456,0.9985208,0.0002522938,0.0003132245,0.0002945141,0.000003649644,0.000007910387,0.000001440448,0.0002327369],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.0025555,"threshold_uncertainty_score":0.01057911,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2043325815050722,"score_gpt":0.387119947375411,"score_spread":0.1827873658703388,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}