{"id":"W2927149912","doi":"10.1039/c8np00076j","title":"Piperazic acid-containing natural products: structures and biosynthesis","year":2019,"lang":"en","type":"review","venue":"Natural Product Reports","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":92,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver Biotech (Canada); University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Polyketide; Biosynthesis; Chemistry; Amino acid; Peptide; Stereochemistry; Biochemistry; Ribosomal RNA; Hydrazine (antidepressant); Combinatorial chemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001895847,0.0006273148,0.0006308603,0.001968813,0.0002000026,0.0007611612,0.0003349983,0.0003777013,0.007117121],"category_scores_gemma":[0.0004340541,0.000196267,0.0002616172,0.001937745,0.0002362387,0.0008858019,0.0004644718,0.0008216329,0.003496633],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003260094,"about_ca_system_score_gemma":0.0005874349,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000533161,"about_ca_topic_score_gemma":0.001021189,"domain_scores_codex":[0.9999005,0.0000117321,0.00001550318,0.00002032021,0.00003844227,0.00001347127],"domain_scores_gemma":[0.9998714,0.00004237967,0.00003134142,0.000005137311,0.00003226342,0.00001740395],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001594498,0.00006802211,0.0003117868,0.02254614,0.0000679771,0.0004043449,0.00008722526,0.0003416649,0.009772815,0.003867389,0.02396408,0.9384091],"study_design_scores_gemma":[0.000007438191,0.00009441505,0.0006770865,0.001721808,0.00005438797,0.001127276,0.00003658881,0.00004201142,0.001792008,0.0009587563,0.9934762,0.00001200284],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0006756386,0.9956879,0.0001356526,0.0001413651,0.0002303697,0.000007074161,0.00009386952,0.00001560823,0.003012516],"genre_scores_gemma":[0.003362617,0.9937463,0.000211904,0.0001392263,0.0001775763,0.000006606339,0.000162669,0.000003761415,0.002189358],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.007117121,"threshold_uncertainty_score":0.02380913,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0319695156249019,"score_gpt":0.3073896414340654,"score_spread":0.2754201258091635,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}