{"id":"W2927298316","doi":"10.1523/jneurosci.0116-19.2019","title":"PTCD1 Is Required for Mitochondrial Oxidative-Phosphorylation: Possible Genetic Association with Alzheimer's Disease","year":2019,"lang":"en","type":"article","venue":"Journal of Neuroscience","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Microsemi (Canada)","funders":"U.S. National Library of Medicine; National Institute of Neurological Disorders and Stroke; National Institute on Deafness and Other Communication Disorders; National Heart, Lung, and Blood Institute; Uniformed Services University of the Health Sciences; Österreichische Forschungsförderungsgesellschaft; National Institute on Aging; Medizinische Universität Graz; Oesterreichische Nationalbank; Erasmus Medisch Centrum; ZonMw; Austrian Science Fund; Russian Foundation for Basic Research; European Commission; Broad Institute; National Alzheimer's Coordinating Center; National Human Genome Research Institute; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; University of Pennsylvania; National Institutes of Health; Karl-Franzens-Universität Graz; U.S. Department of Health and Human Services","keywords":"Mitochondrion; Biology; Oxidative phosphorylation; Mitochondrial DNA; DNAJA3; Cell biology; mitochondrial fusion; Oxidative stress; Neurodegeneration; Human mitochondrial genetics; Alzheimer's disease; Excitotoxicity; Mitochondrial disease; Genetics; Disease; Biochemistry; Gene; Pathology; Medicine; Programmed cell death; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001357356,0.0005087696,0.0003823557,0.001202683,0.0004011473,0.0003273645,0.0003881009,0.0006327264,0.001892597],"category_scores_gemma":[0.0006345653,0.000161484,0.0002582324,0.0009880776,0.0003655778,0.0001174671,0.0003029174,0.0002779048,0.0002569165],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002615342,"about_ca_system_score_gemma":0.0001329212,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001530831,"about_ca_topic_score_gemma":0.001255545,"domain_scores_codex":[0.9998496,0.00001684357,0.00002475712,0.0000564603,0.00003553613,0.00001676467],"domain_scores_gemma":[0.9995579,0.00010945,0.0001990668,0.00002918048,0.00002721482,0.00007720455],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005848829,0.00026431,0.4051136,0.0003789877,0.0005578324,0.03086219,0.0007484552,0.001160133,0.5345708,0.001219584,0.001151293,0.01812396],"study_design_scores_gemma":[0.0001400273,0.0002964853,0.9213639,0.0000478404,0.0005117904,0.02844587,0.0002102303,0.003272918,0.04119641,0.0008538333,0.003617108,0.00004368444],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984068,0.0005710824,0.0003338923,0.00007395489,0.00001153275,0.000005306233,0.0003340646,0.00001856151,0.0002448632],"genre_scores_gemma":[0.9992041,0.0001392708,0.0001981743,0.00002071498,0.00001177655,0.00000322167,0.0002239967,0.000006433635,0.0001924281],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001892597,"threshold_uncertainty_score":0.006331384,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01892871169551121,"score_gpt":0.2652780190852552,"score_spread":0.246349307389744,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}