{"id":"W2927753063","doi":"10.1080/2162402x.2019.1596006","title":"Oncolytic viruses: how “lytic” must they be for therapeutic efficacy?","year":2019,"lang":"en","type":"review","venue":"OncoImmunology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":144,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Oncolytic virus; Lytic cycle; Virotherapy; Immune system; Virus; Mode of action; Viral replication; Virology; Biology; Cancer research; Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001340694,0.0005870767,0.001326778,0.001074344,0.0003853007,0.002442096,0.000951352,0.002535275,0.002123777],"category_scores_gemma":[0.001551069,0.0002517692,0.0003352568,0.0008709535,0.002108352,0.00465382,0.0007876089,0.003827131,0.001863671],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001207177,"about_ca_system_score_gemma":0.00135556,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007000126,"about_ca_topic_score_gemma":0.0007276533,"domain_scores_codex":[0.9996169,0.000100468,0.00005224852,0.0000684162,0.0001239474,0.00003806541],"domain_scores_gemma":[0.9994817,0.0003243773,0.00003734276,0.00002039381,0.0001018178,0.0000343557],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001260357,0.00007143239,0.000254568,0.01230431,0.00005887204,0.0002657835,0.0002164638,0.0004568966,0.007259768,0.09208856,0.04537846,0.8415189],"study_design_scores_gemma":[0.00001408055,0.00007092517,0.0002362748,0.001978565,0.0000286498,0.0009841038,0.0001112499,0.00009106929,0.001088273,0.01435547,0.9810244,0.00001708146],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001388936,0.9952094,0.0003070469,0.002480254,0.0005337943,0.000003349784,0.00001068398,0.000006962627,0.001309568],"genre_scores_gemma":[0.002366242,0.9938643,0.0003687659,0.001630082,0.0006940097,0.00001175058,0.00001982113,0.000004228688,0.001040868],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002535275,"threshold_uncertainty_score":0.008758664,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1303209419327228,"score_gpt":0.4091072281490994,"score_spread":0.2787862862163766,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}