{"id":"W2927857619","doi":"10.1016/j.tiv.2019.03.029","title":"The uremic toxin p-cresol promotes the invasion and migration on carcinoma cells via Ras and mTOR signaling","year":2019,"lang":"en","type":"article","venue":"Toxicology in Vitro","topic":"Renal cell carcinoma treatment","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Chung Shan Medical University Hospital; Ditmanson Medical Foundation Chia-Yi Christian Hospital; Beef Cattle Research Council","keywords":"PI3K/AKT/mTOR pathway; Protein kinase B; Cancer research; Gentamicin protection assay; Cell migration; Cancer cell; Chemistry; MTT assay; Cell; Biology; Cancer; Cell biology; Signal transduction; Medicine; Internal medicine; Metastasis; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00010375,0.0003676905,0.0001932508,0.0003125374,0.0002961939,0.0002509907,0.0001560457,0.0002191506,0.001582621],"category_scores_gemma":[0.000086,0.0001194882,0.0003811482,0.0001811761,0.0002285385,0.0002407312,0.0001735168,0.000724994,0.0002563985],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003482865,"about_ca_system_score_gemma":0.0006540764,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003478973,"about_ca_topic_score_gemma":0.0059154,"domain_scores_codex":[0.9998724,0.00002351704,0.000007784573,0.00001382419,0.00004072913,0.0000417068],"domain_scores_gemma":[0.9999409,0.000008121878,0.00001268412,0.000007591214,0.00001245508,0.00001834809],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005036558,0.0001766859,0.0005852126,0.00008365114,0.00001615642,0.0001575322,0.0000383148,0.0001534866,0.9944266,0.0004932035,0.000220094,0.003145426],"study_design_scores_gemma":[0.00002695801,0.0004864984,0.006236192,0.000008455349,0.00002144353,0.0001457981,0.00008561037,0.0009095313,0.9892951,0.00007362333,0.002705263,0.000005446194],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932163,0.002258754,0.001354592,0.0002824602,0.00005493499,0.00002664635,0.0003190211,0.00007533771,0.002411993],"genre_scores_gemma":[0.9950866,0.001251122,0.0005645229,0.00005491915,0.000007533764,0.00002272476,0.0002626295,0.00000548241,0.002744336],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003478973,"threshold_uncertainty_score":0.006917477,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0149057739708602,"score_gpt":0.2371235332584111,"score_spread":0.2222177592875509,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}