{"id":"W2928316320","doi":"10.1021/acs.analchem.9b00648","title":"Peptide-Mediated Electrochemical Steric Hindrance Assay for One-Step Detection of HIV Antibodies","year":2019,"lang":"en","type":"article","venue":"Analytical Chemistry","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; McGill University; Health Sciences Centre; University of Toronto; Sunnybrook Health Science Centre","funders":"Natural Sciences and Engineering Research Council of Canada; Ontario Ministry of Research, Innovation and Science; Ontario Genomics Institute; Genome Canada","keywords":"Chemistry; Antibody; Steric effects; Peptide; DNA; Conjugated system; Human immunodeficiency virus (HIV); Virus; Gp41; Hybridization probe; Macromolecule; Molecular biology; Virology; Combinatorial chemistry; Biochemistry; Epitope; Stereochemistry; Immunology; Biology; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001546445,0.0001808633,0.0003046131,0.00002445795,0.0000327778,0.00001116916,0.0001536795,0.0002678443,0.000009943839],"category_scores_gemma":[0.0002651933,0.0001698498,0.0002024456,0.0001576694,0.0001166354,0.000004754321,0.00005788112,0.0001264184,0.00000523209],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002369879,"about_ca_system_score_gemma":0.00003827089,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001651838,"about_ca_topic_score_gemma":0.000001976047,"domain_scores_codex":[0.998825,0.0000174238,0.0003021162,0.0004224834,0.0001584254,0.0002745896],"domain_scores_gemma":[0.9991913,0.00005060499,0.0001348669,0.0003515866,0.0001983272,0.00007335411],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001573554,0.00007224065,0.0009428637,0.0001065836,0.000108109,3.875953e-7,0.0000020558,0.000001166276,0.9979492,0.000004184111,0.0003572963,0.0002985398],"study_design_scores_gemma":[0.0003311742,0.0001186776,0.0001653808,0.000028579,0.00007780511,0.000006385237,0.00001976456,0.001840752,0.9919959,0.00003836787,0.005163459,0.0002137252],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9781357,0.0001316349,0.01950151,0.0000930745,0.00001919345,0.000155986,0.00004766148,0.00004346565,0.001871755],"genre_scores_gemma":[0.9944023,0.00006174974,0.002391581,0.0000727088,0.0001328991,0.0000069731,0.0004137059,0.000020569,0.002497492],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01710993,"threshold_uncertainty_score":0.6926275,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00705523269900517,"score_gpt":0.255058847464411,"score_spread":0.2480036147654058,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}