{"id":"W2928679018","doi":"10.1158/1078-0432.ccr-18-2683","title":"Ultra-sensitive <i>EGFR</i> T790M Detection as an Independent Prognostic Marker for Lung Cancer Patients Harboring <i>EGFR</i> del19 Mutations and Treated with First-generation TKIs","year":2019,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"T790M; Lung cancer; Mutation; Medicine; Digital polymerase chain reaction; Internal medicine; Oncology; Cancer; Incidence (geometry); Clinical significance; Tyrosine kinase; Cancer research; Epidermal growth factor receptor; Biology; Gene; Polymerase chain reaction; Gefitinib; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004265213,0.0001477533,0.0002719798,0.0003703742,0.000143646,0.0003591031,0.0001790054,0.0002728949,0.0006708362],"category_scores_gemma":[0.0008138426,0.0001216468,0.0001514056,0.0002270118,0.0002539537,0.0001994393,0.0001775869,0.0002962163,0.0001518183],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002052443,"about_ca_system_score_gemma":0.0001670679,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002862339,"about_ca_topic_score_gemma":0.000381525,"domain_scores_codex":[0.999779,0.00004848586,0.00002182482,0.000062627,0.00005636261,0.00003163764],"domain_scores_gemma":[0.999356,0.0002057772,0.0002531363,0.0000403854,0.00005903069,0.0000856369],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001137318,0.0001013105,0.9491148,0.00002732392,0.00003840157,0.0001367935,0.0000339642,0.0001102726,0.04435027,0.00001937863,0.00006390853,0.004866172],"study_design_scores_gemma":[0.00003026384,0.001046337,0.9748497,0.000005874947,0.00007728628,0.001439316,0.00006041064,0.001557521,0.02051193,0.00004457155,0.0003681444,0.000008662759],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993274,0.0002507289,0.0002184131,0.00001362449,0.000002915604,0.000005909109,0.00005219868,0.00000425229,0.0001245815],"genre_scores_gemma":[0.9995939,0.00004294167,0.000193384,0.00001183416,0.000005055634,0.000004741807,0.00009388594,7.956917e-7,0.00005344606],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006708362,"threshold_uncertainty_score":0.002255678,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06552080965534572,"score_gpt":0.4572230571841265,"score_spread":0.3917022475287807,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}