{"id":"W2928687952","doi":"10.1016/j.immuni.2019.03.005","title":"Loss of Neurological Disease HSAN-I-Associated Gene SPTLC2 Impairs CD8+ T Cell Responses to Infection by Inhibiting T Cell Metabolic Fitness","year":2019,"lang":"en","type":"article","venue":"Immunity","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":55,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"National Institutes of Health; Office of Science; Austrian Science Fund; Horizon 2020 Framework Programme; Deutsches Krebsforschungszentrum; Deutsche Forschungsgemeinschaft; Rare Disease Foundation; National Center for Advancing Translational Sciences; BC Children’s Hospital Foundation; Ministerstvo Zdravotnictví Ceské Republiky; Association Belge contre les Maladies Neuro-Musculaires","keywords":"Biology; Cytotoxic T cell; T cell; CD8; XBP1; Endoplasmic reticulum; mTORC1; Inflammation; Sphingolipid; Intracellular; Immunology; Unfolded protein response; Cell biology; Programmed cell death; Immune system; Signal transduction; Apoptosis; Biochemistry; PI3K/AKT/mTOR pathway; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001207665,0.000559584,0.0002292832,0.0003702609,0.0002304854,0.0003469232,0.0004304122,0.0005261445,0.004260481],"category_scores_gemma":[0.000158579,0.0001794872,0.0003210403,0.0002116511,0.0005607255,0.000160703,0.000284864,0.0009488717,0.0009924269],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003459466,"about_ca_system_score_gemma":0.0003137501,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00103379,"about_ca_topic_score_gemma":0.001716909,"domain_scores_codex":[0.9998447,0.00002688187,0.0000183276,0.00004454118,0.00003376485,0.00003178692],"domain_scores_gemma":[0.9998189,0.00003433994,0.0000534406,0.000020935,0.00001013427,0.00006240651],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001732814,0.0000341076,0.000211048,0.00002405902,0.00001171733,0.0001769247,0.00001026463,0.000138834,0.9981607,0.0001636113,0.00014762,0.0007478992],"study_design_scores_gemma":[0.00009636235,0.0002812676,0.007774294,0.00001762562,0.00005383101,0.001558203,0.00008606373,0.004824772,0.9792412,0.0002498792,0.005798993,0.00001753356],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905579,0.0005029558,0.004341025,0.0003270878,0.000131176,0.0000332275,0.001574445,0.0002885605,0.002243644],"genre_scores_gemma":[0.9941889,0.0001714902,0.001844096,0.00008616763,0.00001582421,0.00003811447,0.0008875815,0.00009764826,0.002670108],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004260481,"threshold_uncertainty_score":0.01425272,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008238087814221749,"score_gpt":0.2371719842146243,"score_spread":0.2289338964004026,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}