{"id":"W2928730330","doi":"10.1371/journal.pgen.1008101","title":"DSB structure impacts DNA recombination leading to class switching and chromosomal translocations in human B cells","year":2019,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; Hospital for Sick Children","keywords":"Biology; Chromosomal translocation; Recombination; Genetics; DNA; Immunoglobulin class switching; Gene; B cell; Antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001073952,0.0001383708,0.00009375922,0.0001448567,0.00008779796,0.0003405238,0.00006815113,0.0002092243,0.001479364],"category_scores_gemma":[0.0001277375,0.0001022218,0.000111754,0.0001306809,0.0000957665,0.00013053,0.0001151829,0.0003137035,0.0002439535],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001784766,"about_ca_system_score_gemma":0.0001083329,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006209497,"about_ca_topic_score_gemma":0.0006093218,"domain_scores_codex":[0.9998401,0.00003480934,0.00001740509,0.00003833537,0.00004293795,0.00002636307],"domain_scores_gemma":[0.9999366,0.00001488855,0.00001628967,0.000006906473,0.00001044798,0.00001476688],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007088729,0.00002043366,0.0003671643,0.00002073235,0.000003814945,0.00002674852,0.00001912633,0.00007569772,0.9984156,0.00004030656,0.00001434406,0.0009251201],"study_design_scores_gemma":[0.00001181841,0.0004886038,0.008938255,0.000005679547,0.0000165422,0.0002614348,0.00006669394,0.0006261499,0.9877881,0.00005579485,0.001736645,0.000004387123],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979004,0.0006906806,0.000406219,0.00002216303,0.000007697533,0.000007481682,0.0001667079,0.00001666431,0.0007820759],"genre_scores_gemma":[0.9984439,0.0003269325,0.0002938476,0.00002829056,0.000002431313,0.000007043568,0.0002165591,0.000004756676,0.0006762486],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001479364,"threshold_uncertainty_score":0.004948914,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006437749248372933,"score_gpt":0.2721289750488462,"score_spread":0.2656912258004733,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}