{"id":"W2928730330","doi":"10.1371/journal.pgen.1008101","title":"DSB structure impacts DNA recombination leading to class switching and chromosomal translocations in human B cells","year":2019,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research; Hospital for Sick Children","keywords":"Biology; Chromosomal translocation; Recombination; Genetics; DNA; Immunoglobulin class switching; Gene; B cell; Antibody","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000667702,0.0001393729,0.0001259069,0.00008515971,0.00004478707,0.00003270571,0.0001076802,0.0001237733,0.0000151778],"category_scores_gemma":[0.00001411994,0.0001554194,0.00002617602,0.0001042858,0.00000953279,0.00000359303,0.00004630701,0.0001003934,0.000005815965],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002018696,"about_ca_system_score_gemma":0.00002189643,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003368368,"about_ca_topic_score_gemma":0.0001395773,"domain_scores_codex":[0.9991942,0.00002335514,0.0001773452,0.0002851635,0.00009527183,0.000224631],"domain_scores_gemma":[0.9996126,0.000009193031,0.0000284681,0.0002242875,0.000033005,0.00009248388],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00000476052,0.00002331139,0.002630563,0.00004806767,0.00001396351,5.740995e-7,0.0003900307,0.00508531,0.9909302,0.00002142124,0.00002722451,0.0008246022],"study_design_scores_gemma":[0.0003756996,0.000188399,0.004869094,0.0000370145,0.00001311195,0.000004296563,0.00008339746,0.002741644,0.9909245,0.00004762827,0.0005146128,0.0002005984],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979962,0.000353408,0.0009139257,0.00008837249,0.0001153417,0.0002925582,0.0000112689,0.00001077607,0.0002181232],"genre_scores_gemma":[0.998796,0.00005207987,0.0008262554,0.0000817754,0.00008621048,0.000006861352,0.00004192101,0.00002859628,0.00008034156],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002343667,"threshold_uncertainty_score":0.6337819,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006437749248372933,"score_gpt":0.2721289750488462,"score_spread":0.2656912258004733,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}