{"id":"W2928738696","doi":"10.1016/j.chom.2019.02.007","title":"Neutrophil Extracellular Traps Confine Pseudomonas aeruginosa Ocular Biofilms and Restrict Brain Invasion","year":2019,"lang":"en","type":"article","venue":"Cell Host & Microbe","topic":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","field":"Immunology and Microbiology","cited_by":197,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research; National Institutes of Health; Alberta Innovates; Alberta Innovates Bio Solutions; National Eye Institute; MedImmune; Academy of Finland; Cystic Fibrosis Canada; Deutsche Forschungsgemeinschaft; Banting Research Foundation; AstraZeneca","keywords":"Biofilm; Pseudomonas aeruginosa; Microbiology; Biology; Virulence; Antibiotics; Keratitis; Type three secretion system; Bacteria; Extracellular; Secretion; Neutrophil extracellular traps; Immunology; Inflammation; Cell biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002427176,0.0003899539,0.0001635536,0.0001681309,0.0002990325,0.0005809444,0.0001801046,0.000526227,0.00211976],"category_scores_gemma":[0.0004165201,0.0001218607,0.0001407515,0.00005825859,0.0002589207,0.0005540359,0.000519097,0.000710096,0.0004251309],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002605556,"about_ca_system_score_gemma":0.0005682543,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001423087,"about_ca_topic_score_gemma":0.004278702,"domain_scores_codex":[0.9997972,0.00004559584,0.000007196746,0.00001757003,0.00004601871,0.00008656376],"domain_scores_gemma":[0.9997876,0.00006028676,0.00005675891,0.00001418331,0.00003558867,0.00004556503],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003266981,0.00006595183,0.0004018387,0.00008863032,0.000007744993,0.0001976059,0.0001146069,0.00009307824,0.9911343,0.0005654671,0.000542802,0.006461252],"study_design_scores_gemma":[0.00008596848,0.001381378,0.01148064,0.00009776359,0.0000330563,0.0008284726,0.0007053675,0.002487771,0.9746869,0.001051015,0.00714044,0.00002133325],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9841141,0.006526141,0.005530185,0.0009633878,0.0001090349,0.00007033359,0.0001533251,0.00005901505,0.002474705],"genre_scores_gemma":[0.9913761,0.00162816,0.002504184,0.0002401397,0.00005879032,0.00005612498,0.00009027561,0.00001337035,0.004032915],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00211976,"threshold_uncertainty_score":0.007091284,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007370431701571723,"score_gpt":0.1971752797872775,"score_spread":0.1898048480857058,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}