{"id":"W2928738696","doi":"10.1016/j.chom.2019.02.007","title":"Neutrophil Extracellular Traps Confine Pseudomonas aeruginosa Ocular Biofilms and Restrict Brain Invasion","year":2019,"lang":"en","type":"article","venue":"Cell Host & Microbe","topic":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","field":"Immunology and Microbiology","cited_by":197,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research; National Institutes of Health; Alberta Innovates; Alberta Innovates Bio Solutions; National Eye Institute; MedImmune; Academy of Finland; Cystic Fibrosis Canada; Deutsche Forschungsgemeinschaft; Banting Research Foundation; AstraZeneca","keywords":"Biofilm; Pseudomonas aeruginosa; Microbiology; Biology; Virulence; Antibiotics; Keratitis; Type three secretion system; Bacteria; Extracellular; Secretion; Neutrophil extracellular traps; Immunology; Inflammation; Cell biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0003447548,0.0005360214,0.0006397626,0.0002644935,0.0002701777,0.00006059654,0.0004147933,0.0005161969,0.001749796],"category_scores_gemma":[0.00002395631,0.0004843628,0.0001907925,0.0003046011,0.0002934404,0.0001769012,0.0002568454,0.0006504058,0.003037266],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004435974,"about_ca_system_score_gemma":0.00008572036,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001069461,"about_ca_topic_score_gemma":0.000007271839,"domain_scores_codex":[0.99736,0.0003376021,0.0005111906,0.0009490571,0.00007340008,0.0007687566],"domain_scores_gemma":[0.9986649,0.0001901732,0.0002197984,0.0007305183,0.0000955587,0.00009904349],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001641611,0.0001936447,0.0005600826,0.00007563406,0.00007640861,0.0001012908,0.0002310133,0.000001592856,0.9911537,0.001493568,0.004774054,0.001174861],"study_design_scores_gemma":[0.002789191,0.0004892111,0.001110193,0.0000621231,0.00005791869,0.0001718565,0.0001891123,0.000002255523,0.8045653,0.0000800022,0.1900048,0.0004780659],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9798594,0.01584593,0.0001180912,0.0009835312,0.0007755088,0.000812608,0.00008171979,0.0001249343,0.001398298],"genre_scores_gemma":[0.9826695,0.0009227862,0.0003086867,0.001043897,0.00006576612,0.0000207362,0.0003019288,0.00007372918,0.014593],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1865884,"threshold_uncertainty_score":0.9997608,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007370431701571723,"score_gpt":0.1971752797872775,"score_spread":0.1898048480857058,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}